Lung function and pulmonary biomarkers in children chronically exposed to arsenic in drinking water

E. H. Olivas Calderón, J. A. Espinosa Fematt, R. Recio Vega, G. Ocampo Gómez, T. Cortes González, Robert Clark Lantz, A Jay Gandolfi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The objective of this study was to determine whether arsenic exposure is associated with changes in biomarkers of lung inflammation measured by the ratio of metalloproteinase 9 (MMP-9)/tissue inhibitor of metalloproteinase (TIMP-1), levels of soluble form of Receptor for Advanced Glycation End products (RAGE) in sputum and with decreased lung capacity. Tap water of communities and first morning void urine were analyzed for arsenic. Arsenic levels in this region are 50-120 μg/L in drinking water. Total arsenic urinary (median) was higher in subjects with restrictive spirometric patterns than normal spirometric patterns subjects (123.7 vs. 92.9) (p < 0.05). In addition, we observed significantly decreased in ratio MMP-9/TIMP1 and RAGE levels [median (range)] in subjects with restrictive spirometric patterns in comparison with subjects normal [23.21 (17.5, 37.4) vs. 9.0 (3.5,16.4)] and [46.7 (34.4-71.3) vs. 31.2 (20.3-43.2)] respectively. This finding suggests a potential toxic mechanism in lung for arsenic exposure.

Original languageEnglish (US)
Title of host publicationOne Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PublisherCRC Press/Balkema
Pages578-579
Number of pages2
ISBN (Print)9781138001411
StatePublished - 2014
Event5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina
Duration: May 11 2014May 16 2014

Other

Other5th International Congress on Arsenic in the Environment, As 2014
CountryArgentina
CityBuenos Aires
Period5/11/145/16/14

Fingerprint

Arsenic
Biomarkers
Potable water
Drinking Water
Tissue Inhibitor of Metalloproteinases
Tissue Inhibitor of Metalloproteinase-1
Poisons
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Tissue
Water
Advanced Glycosylation End Product-Specific Receptor
Metalloproteases

ASJC Scopus subject areas

  • Chemical Health and Safety

Cite this

Olivas Calderón, E. H., Espinosa Fematt, J. A., Recio Vega, R., Ocampo Gómez, G., Cortes González, T., Lantz, R. C., & Gandolfi, A. J. (2014). Lung function and pulmonary biomarkers in children chronically exposed to arsenic in drinking water. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 578-579). CRC Press/Balkema.

Lung function and pulmonary biomarkers in children chronically exposed to arsenic in drinking water. / Olivas Calderón, E. H.; Espinosa Fematt, J. A.; Recio Vega, R.; Ocampo Gómez, G.; Cortes González, T.; Lantz, Robert Clark; Gandolfi, A Jay.

One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. p. 578-579.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Olivas Calderón, EH, Espinosa Fematt, JA, Recio Vega, R, Ocampo Gómez, G, Cortes González, T, Lantz, RC & Gandolfi, AJ 2014, Lung function and pulmonary biomarkers in children chronically exposed to arsenic in drinking water. in One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, pp. 578-579, 5th International Congress on Arsenic in the Environment, As 2014, Buenos Aires, Argentina, 5/11/14.
Olivas Calderón EH, Espinosa Fematt JA, Recio Vega R, Ocampo Gómez G, Cortes González T, Lantz RC et al. Lung function and pulmonary biomarkers in children chronically exposed to arsenic in drinking water. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema. 2014. p. 578-579
Olivas Calderón, E. H. ; Espinosa Fematt, J. A. ; Recio Vega, R. ; Ocampo Gómez, G. ; Cortes González, T. ; Lantz, Robert Clark ; Gandolfi, A Jay. / Lung function and pulmonary biomarkers in children chronically exposed to arsenic in drinking water. One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. pp. 578-579
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