Lung function and pulmonary biomarkers in children chronically exposed to arsenic in drinking water

E. H. Olivas Calderón, J. A. Espinosa Fematt, R. Recio Vega, G. Ocampo Gómez, T. Cortes González, R. C. Lantz, A. J. Gandolfi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The objective of this study was to determine whether arsenic exposure is associated with changes in biomarkers of lung inflammation measured by the ratio of metalloproteinase 9 (MMP-9)/tissue inhibitor of metalloproteinase (TIMP-1), levels of soluble form of Receptor for Advanced Glycation End products (RAGE) in sputum and with decreased lung capacity. Tap water of communities and first morning void urine were analyzed for arsenic. Arsenic levels in this region are 50-120 μg/L in drinking water. Total arsenic urinary (median) was higher in subjects with restrictive spirometric patterns than normal spirometric patterns subjects (123.7 vs. 92.9) (p < 0.05). In addition, we observed significantly decreased in ratio MMP-9/TIMP1 and RAGE levels [median (range)] in subjects with restrictive spirometric patterns in comparison with subjects normal [23.21 (17.5, 37.4) vs. 9.0 (3.5,16.4)] and [46.7 (34.4-71.3) vs. 31.2 (20.3-43.2)] respectively. This finding suggests a potential toxic mechanism in lung for arsenic exposure.

Original languageEnglish (US)
Title of host publicationOne Century of the Discovery of Arsenicosis in Latin America (1914-2014)
Subtitle of host publicationAs 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PublisherCRC Press/Balkema
Pages578-579
Number of pages2
ISBN (Print)9781138001411
StatePublished - Jan 1 2014
Event5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina
Duration: May 11 2014May 16 2014

Publication series

NameOne Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment

Other

Other5th International Congress on Arsenic in the Environment, As 2014
CountryArgentina
CityBuenos Aires
Period5/11/145/16/14

ASJC Scopus subject areas

  • Chemical Health and Safety

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