Lung growth through the "life course" and predictors and determinants of chronic respiratory disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Strong observational and experimental evidence indicates that lung growth during fetal and early postnatal life is one of the strongest determinants of adult lung function. Genetic variation plays a critical role in determining maximal lung function reached in adult life. Factors that affect lung growth such as extreme prematurity with bronchopulmonary dysplasia, intrauterine growth retardation, exposure to tobacco smoke in utero and postnatally, and vitamin A and D deficiencies also play varying roles in determining lung function. However, catch-up growth seems to be able to reverse at least in part the negative effects of some of these conditions. Individuals who reach early adult life with lower levels of lung function are at increased risk of developing chronic obstructive pulmonary disease during the decline phase of lung function, after the third decade of life, and may also be more susceptible to the deleterious effects of active cigarette smoking.

Original languageEnglish (US)
Title of host publicationFetal and Neonatal Lung Development
Subtitle of host publicationClinical Correlates and Technologies for the Future
PublisherCambridge University Press
Pages286-302
Number of pages17
ISBN (Electronic)9781139680349
ISBN (Print)9781107072091
DOIs
StatePublished - Apr 18 2016

Keywords

  • Bronchopulmonary dysplasia
  • Chronic obstructive pulmonary disease
  • Intrauterine growth retardation
  • Lung function
  • Prematurity

ASJC Scopus subject areas

  • Medicine(all)

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