Lymphatic communication

Connexin junction, what's your function?

J. D. Kanady, Alex Simon

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This article reviews recent findings on expression and function of connexin proteins - the structural subunits of gap junction intercellular channels in the lymphatic vasculature - both during development and in the mature lymphatic vessel. Highlighted in particular are recent mouse connexin knockout studies which show that connexins are crucial for normal lymphatic development. We discuss, in general terms, both channel-dependent as well as channel-independent functions of connexins and raise some of the many unanswered questions about the mechanism(s) of action and physiological roles of connexins in the lymphatic vasculature.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalLymphology
Volume44
Issue number3
StatePublished - Sep 2011

Fingerprint

Connexins
Communication
Lymphatic Vessels
Gap Junctions
Protein Subunits
Knockout Mice

Keywords

  • Connexin
  • Gap junction
  • Lymphatic development
  • Lymphatic valve
  • Lymphatic vasculature

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

Cite this

Lymphatic communication : Connexin junction, what's your function? / Kanady, J. D.; Simon, Alex.

In: Lymphology, Vol. 44, No. 3, 09.2011, p. 95-102.

Research output: Contribution to journalArticle

@article{1ad1139b28774fa6b07f1cb0eee41382,
title = "Lymphatic communication: Connexin junction, what's your function?",
abstract = "This article reviews recent findings on expression and function of connexin proteins - the structural subunits of gap junction intercellular channels in the lymphatic vasculature - both during development and in the mature lymphatic vessel. Highlighted in particular are recent mouse connexin knockout studies which show that connexins are crucial for normal lymphatic development. We discuss, in general terms, both channel-dependent as well as channel-independent functions of connexins and raise some of the many unanswered questions about the mechanism(s) of action and physiological roles of connexins in the lymphatic vasculature.",
keywords = "Connexin, Gap junction, Lymphatic development, Lymphatic valve, Lymphatic vasculature",
author = "Kanady, {J. D.} and Alex Simon",
year = "2011",
month = "9",
language = "English (US)",
volume = "44",
pages = "95--102",
journal = "Lymphology",
issn = "0024-7766",
publisher = "International Society of Lymphology",
number = "3",

}

TY - JOUR

T1 - Lymphatic communication

T2 - Connexin junction, what's your function?

AU - Kanady, J. D.

AU - Simon, Alex

PY - 2011/9

Y1 - 2011/9

N2 - This article reviews recent findings on expression and function of connexin proteins - the structural subunits of gap junction intercellular channels in the lymphatic vasculature - both during development and in the mature lymphatic vessel. Highlighted in particular are recent mouse connexin knockout studies which show that connexins are crucial for normal lymphatic development. We discuss, in general terms, both channel-dependent as well as channel-independent functions of connexins and raise some of the many unanswered questions about the mechanism(s) of action and physiological roles of connexins in the lymphatic vasculature.

AB - This article reviews recent findings on expression and function of connexin proteins - the structural subunits of gap junction intercellular channels in the lymphatic vasculature - both during development and in the mature lymphatic vessel. Highlighted in particular are recent mouse connexin knockout studies which show that connexins are crucial for normal lymphatic development. We discuss, in general terms, both channel-dependent as well as channel-independent functions of connexins and raise some of the many unanswered questions about the mechanism(s) of action and physiological roles of connexins in the lymphatic vasculature.

KW - Connexin

KW - Gap junction

KW - Lymphatic development

KW - Lymphatic valve

KW - Lymphatic vasculature

UR - http://www.scopus.com/inward/record.url?scp=84855414089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855414089&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 95

EP - 102

JO - Lymphology

JF - Lymphology

SN - 0024-7766

IS - 3

ER -