Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L. Harvey; R. Sathish Srinivasan; Miriam E. Dillard; Nicole C. Johnson; Marlys H. Witte; Kelli Boyd; Mark W. Sleeman; Guillermo Oliver

doi:10.1038/ng1642

Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L. Harvey, R. Sathish Srinivasan, Miriam E. Dillard, Nicole C. Johnson, Marlys H. Witte, Kelli Boyd, Mark W. Sleeman, Guillermo Oliver

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352 Scopus citations

Abstract

Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.

Original language	English (US)
Pages (from-to)	1072-1081
Number of pages	10
Journal	Nature Genetics
Volume	37
Issue number	10
DOIs	https://doi.org/10.1038/ng1642
State	Published - Oct 1 2005

ASJC Scopus subject areas

Genetics

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Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. / Harvey, Natasha L.; Srinivasan, R. Sathish; Dillard, Miriam E.; Johnson, Nicole C.; Witte, Marlys H.; Boyd, Kelli; Sleeman, Mark W.; Oliver, Guillermo.

In: Nature Genetics, Vol. 37, No. 10, 01.10.2005, p. 1072-1081.

Research output: Contribution to journal › Article › peer-review

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Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

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