Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L. Harvey; R. Sathish Srinivasan; Miriam E. Dillard; Nicole C. Johnson; Marlys H Witte; Kelli Boyd; Mark W. Sleeman; Guillermo Oliver

doi:10.1038/ng1642

Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L. Harvey, R. Sathish Srinivasan, Miriam E. Dillard, Nicole C. Johnson, Marlys H Witte, Kelli Boyd, Mark W. Sleeman, Guillermo Oliver

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Abstract

Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.

Original language	English (US)
Pages (from-to)	1072-1081
Number of pages	10
Journal	Nature Genetics
Volume	37
Issue number	10
DOIs	https://doi.org/10.1038/ng1642
Publication status	Published - Oct 2005

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ASJC Scopus subject areas

Genetics(clinical)
Genetics

Cite this

Harvey, N. L., Srinivasan, R. S., Dillard, M. E., Johnson, N. C., Witte, M. H., Boyd, K., ... Oliver, G. (2005). Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nature Genetics, 37(10), 1072-1081. https://doi.org/10.1038/ng1642

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10.1038/ng1642