Abstract
Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
Original language | English (US) |
---|---|
Pages (from-to) | 1072-1081 |
Number of pages | 10 |
Journal | Nature Genetics |
Volume | 37 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2005 |
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ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. / Harvey, Natasha L.; Srinivasan, R. Sathish; Dillard, Miriam E.; Johnson, Nicole C.; Witte, Marlys H; Boyd, Kelli; Sleeman, Mark W.; Oliver, Guillermo.
In: Nature Genetics, Vol. 37, No. 10, 10.2005, p. 1072-1081.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
AU - Harvey, Natasha L.
AU - Srinivasan, R. Sathish
AU - Dillard, Miriam E.
AU - Johnson, Nicole C.
AU - Witte, Marlys H
AU - Boyd, Kelli
AU - Sleeman, Mark W.
AU - Oliver, Guillermo
PY - 2005/10
Y1 - 2005/10
N2 - Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
AB - Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
UR - http://www.scopus.com/inward/record.url?scp=27144478129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27144478129&partnerID=8YFLogxK
U2 - 10.1038/ng1642
DO - 10.1038/ng1642
M3 - Article
C2 - 16170315
AN - SCOPUS:27144478129
VL - 37
SP - 1072
EP - 1081
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 10
ER -