Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L. Harvey, R. Sathish Srinivasan, Miriam E. Dillard, Nicole C. Johnson, Marlys H. Witte, Kelli Boyd, Mark W. Sleeman, Guillermo Oliver

Research output: Contribution to journalArticlepeer-review

386 Scopus citations

Abstract

Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.

Original languageEnglish (US)
Pages (from-to)1072-1081
Number of pages10
JournalNature Genetics
Volume37
Issue number10
DOIs
StatePublished - Oct 1 2005

ASJC Scopus subject areas

  • Genetics

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