Lymphocyte activation: A rapid test to predict allograft rejection

Evan M. Hersh, William T. Butler, Roger D. Rossen, Robert O. Morgen

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

THE early detection of allograft rejection, before organ function deteriorates, is an important objective of clinical research in transplantation immunology. Because lymphocytes play a central part in graft rejection 1,2, attention was focused on these cells in the circulation of graft recipients. We observed that the numbers of circulating lymphocytes that incorporate3H-thymidine rise significantly during organ allograft rejection and may predict rejection crises by 24-48 h.

Original languageEnglish (US)
Pages (from-to)757-758
Number of pages2
JournalNature
Volume226
Issue number5247
DOIs
StatePublished - Dec 1 1970

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Hersh, E. M., Butler, W. T., Rossen, R. D., & Morgen, R. O. (1970). Lymphocyte activation: A rapid test to predict allograft rejection. Nature, 226(5247), 757-758. https://doi.org/10.1038/226757a0