Lymphocyte blastogenic responses to autochthonous viable and nonviable human tumor cells

G. M. Mavligit, E. M. Hersh, C. M. McBride

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

In vitro blastogenic response to autochthonous tumor cells was studied in 11 patients with solid tumors. After viable cells were separated from nonviable tumor cells by differential centrifugation on Ficoll Hypaque density solution, they were exposed to irradiation, mitomycin C, or no treatment. These conditions produced tumor cell preparations with various degrees of stimulatory ability. Viable tumor cells have some advantage over nonviable tumor cells, and irradiated tumor cells were superior to those treated with mitomycin C in terms of tumor induced blastogenesis among autologous lymphocytes.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalJournal of the National Cancer Institute
Volume51
Issue number2
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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