Lymphomatoid granulomatosis. Report of a case and review of the literature

Roger C. Bone, Mary Vernon, Richard E Sobonya, Humberto Rendon

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A 24 year old man had a nonproductive cough and chest pain. Chest roentgenogram showed a diffuse infiltrate, and pulmonary function studies showed restrictive lung disease. Extremity weakness, deteriorating mental status and neuropathy progressed as pulmonary findings diminished on corticosteroid therapy. Lung biopsy showed lymphomatoid granulomatosis. The neurologic status deteriorated despite treatment with Cytoxan®, intrathecal metnotrexate and brain irradiation. Autopsy showed mass lesions of lymphomatoid granulomatosis in the brain and healed lesions in the lungs. A review of the neurologic and pulmonary findings in reported cases show that diminution of pulmonary disease with progression of neurologic disease manifest by mass lesion is unusual. Since the etiology, prognosis and prevalence of this disease remains undefined, all patients with this disease should be reported on.

Original languageEnglish (US)
Pages (from-to)709-716
Number of pages8
JournalAmerican Journal of Medicine
Volume65
Issue number4
DOIs
StatePublished - 1978
Externally publishedYes

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Lymphomatoid Granulomatosis
Lung
Lung Diseases
Brain
Neurologic Manifestations
Nervous System Diseases
Chest Pain
Cough
Cyclophosphamide
Nervous System
Disease Progression
Autopsy
Adrenal Cortex Hormones
Thorax
Extremities
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Lymphomatoid granulomatosis. Report of a case and review of the literature. / Bone, Roger C.; Vernon, Mary; Sobonya, Richard E; Rendon, Humberto.

In: American Journal of Medicine, Vol. 65, No. 4, 1978, p. 709-716.

Research output: Contribution to journalArticle

Bone, Roger C. ; Vernon, Mary ; Sobonya, Richard E ; Rendon, Humberto. / Lymphomatoid granulomatosis. Report of a case and review of the literature. In: American Journal of Medicine. 1978 ; Vol. 65, No. 4. pp. 709-716.
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