Lymphoproliferative disorder of the airway of an adolescent without immunodeficiency

R. P. Boesch, Michael O Daines, A. Kaul, R. Cotton, R. Amin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Epstein-Barr virus (EBV) is a ubiquitous viral pathogen in humans that has a unique ability to immortalize B-cells. In immunosuppressed individuals, EBV can produce non-neoplastic lymphoproliferative disorders involving various organs. We describe a case report of EBV-associated lymphoproliferative disorder in an immunocompetent 14-year-old male. The case provides a description of EBV-associated lymphoproliferation affecting the upper and lower respiratory tract. The massive submucosal infiltration of B-cells in the lingual tonsils, trachea, and bronchi produced near-complete airway obstruction resulting in tracheotomy. Neither surgical reduction of lingual tonsils nor treatment with steroids was of benefit. An extensive evaluation for immunodeficiency and neoplasia was normal. Treatment with rituximab, an anti-CD20 antibody, resulted in near-complete resolution of the infiltrative process, sufficient to allow decannulation. Rituximab is a treatment option for the rare occurrence of non-neoplastic, EBV-associated, lymphoproliferative disorders.

Original languageEnglish (US)
Pages (from-to)1591-1594
Number of pages4
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume69
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Lymphoproliferative Disorders
Human Herpesvirus 4
Palatine Tonsil
Tongue
B-Lymphocytes
Tracheotomy
Airway Obstruction
Bronchi
Trachea
Respiratory System
Anti-Idiotypic Antibodies
Therapeutics
Steroids
Neoplasms

Keywords

  • Epstein-Barr virus
  • Lymphoproliferative disorder
  • Rituximab

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Lymphoproliferative disorder of the airway of an adolescent without immunodeficiency. / Boesch, R. P.; Daines, Michael O; Kaul, A.; Cotton, R.; Amin, R.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 69, No. 11, 11.2005, p. 1591-1594.

Research output: Contribution to journalArticle

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