Macrophage antiviral activity: Extrinsic versus intrinsic activity

S. A. Stohlman, J. G. Woodward, Jeffrey A Frelinger

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Peritoneal exudate cells from strains of mice both resistant and susceptible to challenge with mouse hepatitis virus strain JHM were examined for extrinsic and intrinsic antiviral activity. Thioglycolate-elicited and resident peritoneal cells from uninfected mice were able to suppress viral growth in a permissive cell. The active cell in both populations is an adherent, radiation-resistant, Thy-1,2 antigen- and Ia antigen-negative cell. The suppression of virus replication was not related to nonspecific cellular cytotoxicity directed against the permissive host cell, and no interferon was detected. The expression of extrinsic antiviral activity was not related to the ability of the host to resist mouse hepatitis virus infection by virtue of either age or genetic backgroud. The expression of intrinsic antiviral activity, on the other hand, correlated with the ability of the host to resist virus challenge, indicating a characteristic distinction between these two in vitro mechanisms of macrophage-mediated antiviral activity with regard to host resistance to viral infection. Further, the ability of a macrophage to support viral replication itself was independent of the ability of the macrophage to suppress virus growth in another cell.

Original languageEnglish (US)
Pages (from-to)672-677
Number of pages6
JournalInfection and Immunity
Volume36
Issue number2
StatePublished - 1982
Externally publishedYes

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Antiviral Agents
Macrophages
Murine hepatitis virus
Virus Diseases
Thy-1 Antigens
Viruses
Thioglycolates
Histocompatibility Antigens Class II
Exudates and Transudates
Virus Replication
Growth
Interferons
Radiation
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Macrophage antiviral activity : Extrinsic versus intrinsic activity. / Stohlman, S. A.; Woodward, J. G.; Frelinger, Jeffrey A.

In: Infection and Immunity, Vol. 36, No. 2, 1982, p. 672-677.

Research output: Contribution to journalArticle

Stohlman, S. A. ; Woodward, J. G. ; Frelinger, Jeffrey A. / Macrophage antiviral activity : Extrinsic versus intrinsic activity. In: Infection and Immunity. 1982 ; Vol. 36, No. 2. pp. 672-677.
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