Macrophage migration inhibitory factor: Controller of systemic inflammation

Douglas F. Larson, Katherine Horak

Research output: Contribution to journalComment/debate

52 Scopus citations


Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system, namely the T-helper (Th)1 and Th2 lymphocytes, which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function.

Original languageEnglish (US)
Article number138
JournalCritical Care
Issue number2
StatePublished - Apr 6 2006


ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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