Macrophages and resistance to JHM virus CNS infection.

S. A. Stohlman, Jeffrey A Frelinger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Thioglycollate elicited peritoneal exudate cells from resistant SJL mice, younger susceptible SJL mice, and susceptible ASW, BALB/c, and C57/BL6 mice all exhibit extrinsic antiviral activity. The active cell was characterized as a Thy 1.2 negative, Ia negative, radiation resistant adherent cell. The antiviral activity was not due to nonspecific cellular cytotoxicity directed against the susceptible cell nor interferon. Adherent PE cells from resistant and susceptible SJL mice were similar with respect to the number of phagocytes, nonspecific esterase containing, Fc, and C3b receptor bearing cells. Finally, extrinsic antiviral activity was not dependent upon intrinsic antiviral activity.

Original languageEnglish (US)
Pages (from-to)387-398
Number of pages12
JournalAdvances in Experimental Medicine and Biology
Volume142
StatePublished - 1981
Externally publishedYes

Fingerprint

Macrophages
Virus Diseases
Viruses
Antiviral Agents
Bearings (structural)
Complement 3b Receptors
Thioglycolates
Carboxylesterase
Fc Receptors
Cytotoxicity
Interferons
Exudates and Transudates
Phagocytes
Radiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Macrophages and resistance to JHM virus CNS infection. / Stohlman, S. A.; Frelinger, Jeffrey A.

In: Advances in Experimental Medicine and Biology, Vol. 142, 1981, p. 387-398.

Research output: Contribution to journalArticle

@article{7904363958b344f48f1be842ce5834f0,
title = "Macrophages and resistance to JHM virus CNS infection.",
abstract = "Thioglycollate elicited peritoneal exudate cells from resistant SJL mice, younger susceptible SJL mice, and susceptible ASW, BALB/c, and C57/BL6 mice all exhibit extrinsic antiviral activity. The active cell was characterized as a Thy 1.2 negative, Ia negative, radiation resistant adherent cell. The antiviral activity was not due to nonspecific cellular cytotoxicity directed against the susceptible cell nor interferon. Adherent PE cells from resistant and susceptible SJL mice were similar with respect to the number of phagocytes, nonspecific esterase containing, Fc, and C3b receptor bearing cells. Finally, extrinsic antiviral activity was not dependent upon intrinsic antiviral activity.",
author = "Stohlman, {S. A.} and Frelinger, {Jeffrey A}",
year = "1981",
language = "English (US)",
volume = "142",
pages = "387--398",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer New York",

}

TY - JOUR

T1 - Macrophages and resistance to JHM virus CNS infection.

AU - Stohlman, S. A.

AU - Frelinger, Jeffrey A

PY - 1981

Y1 - 1981

N2 - Thioglycollate elicited peritoneal exudate cells from resistant SJL mice, younger susceptible SJL mice, and susceptible ASW, BALB/c, and C57/BL6 mice all exhibit extrinsic antiviral activity. The active cell was characterized as a Thy 1.2 negative, Ia negative, radiation resistant adherent cell. The antiviral activity was not due to nonspecific cellular cytotoxicity directed against the susceptible cell nor interferon. Adherent PE cells from resistant and susceptible SJL mice were similar with respect to the number of phagocytes, nonspecific esterase containing, Fc, and C3b receptor bearing cells. Finally, extrinsic antiviral activity was not dependent upon intrinsic antiviral activity.

AB - Thioglycollate elicited peritoneal exudate cells from resistant SJL mice, younger susceptible SJL mice, and susceptible ASW, BALB/c, and C57/BL6 mice all exhibit extrinsic antiviral activity. The active cell was characterized as a Thy 1.2 negative, Ia negative, radiation resistant adherent cell. The antiviral activity was not due to nonspecific cellular cytotoxicity directed against the susceptible cell nor interferon. Adherent PE cells from resistant and susceptible SJL mice were similar with respect to the number of phagocytes, nonspecific esterase containing, Fc, and C3b receptor bearing cells. Finally, extrinsic antiviral activity was not dependent upon intrinsic antiviral activity.

UR - http://www.scopus.com/inward/record.url?scp=0019743461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019743461&partnerID=8YFLogxK

M3 - Article

C2 - 6278893

AN - SCOPUS:0019743461

VL - 142

SP - 387

EP - 398

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -