Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing

Data from the osteoarthritis initiative

Felix Eckstein, Olivier Benichou, Wolfgang Wirth, David R. Nelson, Susanne Maschek, Martin Hudelmaier, Chian K Kwoh, Ali Guermazi, David Hunter

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective. To determine by magnetic resonance imaging (MRI), whether knees with advanced radiographic disease (medial joint space narrowing [mJSN]) encounter greater longitudinal cartilage loss than contralateral knees with earlier disease (no or less mJSN). Methods. Participants were selected from 2,678 cases in the Osteoarthritis Initiative, based on exhibition of bilateral pain, body mass index >25 (kg/m 2), mJSN in 1 knee, no or less mJSN in the contralateral knee, and no lateral JSN in both knees. Eighty participants (mean ± SD age 60.6 ± 9.1 years) fulfilled these criteria. Medial tibial and femoral cartilage morphology was analyzed from the baseline and the 1-year followup MRI (sagittal double echo at steady state by 3.0T) of both knees by experienced readers blinded to the time point and mJSN status. Results. Knees with more radiographic mJSN displayed greater medial cartilage loss (-80 μm) assessed by MRI than contralateral knees with less mJSN (-57 μm). The difference reached statistical significance in participants with an mJSN grade of 2 or 3 (P = 0.005-0.08), but not in participants with an mJSN grade of 1 (P = 0.28-0.98). In knees with more mJSN, cartilage loss increased with higher grades of mJSN (P = 0.003 in the medial femur). Knees with an mJSN grade of 2 or 3 displayed greater cartilage loss in the weight-bearing medial femur than in the posterior femur or in the medial tibia (P = 0.048). Conclusion. Knees with advanced mJSN displayed greater cartilage loss than contralateral knees with less mJSN. These data suggest that radiography can be used to stratify fast structural progressors, and that MRI cartilage thickness loss is more pronounced at advanced radiographic disease stage.

Original languageEnglish (US)
Pages (from-to)1218-1225
Number of pages8
JournalArthritis Care and Research
Volume61
Issue number9
DOIs
StatePublished - Sep 15 2009
Externally publishedYes

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Osteoarthritis
Cartilage
Knee
Joints
Magnetic Resonance Imaging
Femur
Joint Diseases
Weight-Bearing
Thigh
Tibia
Radiography
Body Mass Index
Pain

ASJC Scopus subject areas

  • Rheumatology

Cite this

Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing : Data from the osteoarthritis initiative. / Eckstein, Felix; Benichou, Olivier; Wirth, Wolfgang; Nelson, David R.; Maschek, Susanne; Hudelmaier, Martin; Kwoh, Chian K; Guermazi, Ali; Hunter, David.

In: Arthritis Care and Research, Vol. 61, No. 9, 15.09.2009, p. 1218-1225.

Research output: Contribution to journalArticle

Eckstein, Felix ; Benichou, Olivier ; Wirth, Wolfgang ; Nelson, David R. ; Maschek, Susanne ; Hudelmaier, Martin ; Kwoh, Chian K ; Guermazi, Ali ; Hunter, David. / Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing : Data from the osteoarthritis initiative. In: Arthritis Care and Research. 2009 ; Vol. 61, No. 9. pp. 1218-1225.
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abstract = "Objective. To determine by magnetic resonance imaging (MRI), whether knees with advanced radiographic disease (medial joint space narrowing [mJSN]) encounter greater longitudinal cartilage loss than contralateral knees with earlier disease (no or less mJSN). Methods. Participants were selected from 2,678 cases in the Osteoarthritis Initiative, based on exhibition of bilateral pain, body mass index >25 (kg/m 2), mJSN in 1 knee, no or less mJSN in the contralateral knee, and no lateral JSN in both knees. Eighty participants (mean ± SD age 60.6 ± 9.1 years) fulfilled these criteria. Medial tibial and femoral cartilage morphology was analyzed from the baseline and the 1-year followup MRI (sagittal double echo at steady state by 3.0T) of both knees by experienced readers blinded to the time point and mJSN status. Results. Knees with more radiographic mJSN displayed greater medial cartilage loss (-80 μm) assessed by MRI than contralateral knees with less mJSN (-57 μm). The difference reached statistical significance in participants with an mJSN grade of 2 or 3 (P = 0.005-0.08), but not in participants with an mJSN grade of 1 (P = 0.28-0.98). In knees with more mJSN, cartilage loss increased with higher grades of mJSN (P = 0.003 in the medial femur). Knees with an mJSN grade of 2 or 3 displayed greater cartilage loss in the weight-bearing medial femur than in the posterior femur or in the medial tibia (P = 0.048). Conclusion. Knees with advanced mJSN displayed greater cartilage loss than contralateral knees with less mJSN. These data suggest that radiography can be used to stratify fast structural progressors, and that MRI cartilage thickness loss is more pronounced at advanced radiographic disease stage.",
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AU - Nelson, David R.

AU - Maschek, Susanne

AU - Hudelmaier, Martin

AU - Kwoh, Chian K

AU - Guermazi, Ali

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