Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease – data from the Osteoarthritis Initiative

B. L. Wise, J. Niu, A. Guermazi, F. Liu, U. Heilmeier, E. Ku, J. A. Lynch, Y. Zhang, D. T. Felson, Chian K Kwoh, N. E. Lane

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4 Scopus citations


Objective Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis (OA). The objective of the present study was to characterize Magnetic Resonance Imaging (MRI) abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA. Method 200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade ≥ 2 and joint space narrowing (JSN) > 0 in the lateral compartment but JSN = 0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit. 200 cases with IM-ROA and 200 controls were frequency matched to the IL-ROA cases. Cases and controls were analyzed for odds of having a subregion with >10% cartilage area affected, with ≥25% bone marrow lesions (BML), with meniscal tear or maceration, and for association with cartilage T2 values. Results IL-ROA was more strongly associated with ipsilateral MRI knee pathologies than IM-ROA (IL-ROA: OR = 135.2 for size of cartilage lesion, 95% CI 42.7–427.4; OR = 145.4 for large size BML, 95% CI 41.5–509.5; OR = 176 for meniscal tears, 95% CI 59.8–517.7; IM-ROA: OR = 28.4 for size of cartilage lesion, 95% CI 14.7–54.7; OR = 38.1 for size of BML, 95% CI 12.7–114; OR = 37.0 for meniscal tears, 95% CI 12–113.6). Cartilage T2 values were higher in both tibial and medial femoral compartments in IL-ROA, but in IM-ROA were only significantly different from controls in the medial femur. Conclusion IL-ROA knees show a greater prevalence and severity of MRI lesions and higher cartilage T2 values than IM-ROA knees compared with controls.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalOsteoarthritis and Cartilage
Issue number1
StatePublished - Jan 1 2017



  • Cartilage
  • Knee osteoarthritis
  • Lateral compartment
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine
  • Biomedical Engineering

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