Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke

Jaywant P. Parmar, Walter J. Rogers, John P. Mugler, Erol Baskurt, Talissa A. Altes, Kiran R. Nandalur, George J. Stukenborg, C. Douglas Phillips, Klaus D. Hagspiel, Alan H. Matsumoto, Michael D. Dake, Christopher M. Kramer

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background: Carotid atherosclerotic plaque rupture is thought to cause transient ischemic attack (TIA) and ischemic stroke (IS). Pathological hallmarks of these plaques have been identified through observational studies. Although generally accepted, the relationship between cerebral thromboembolism and in situ atherosclerotic plaque morphology has never been directly observed noninvasively in the acute setting. Methods and Results: Consecutive acutely symptomatic patients referred for stroke protocol magnetic resonance imaging/angiography underwent additional T1- and T2-weighted carotid bifurcation imaging with the use of a 3-dimensional technique with blood signal suppression. Two blinded reviewers performed plaque gradings according to the American Heart Association classification system. Discharge outcomes and brain magnetic resonance imaging results were obtained. Image quality for plaque characterization was adequate in 86 of 106 patients (81%). Eight TIA/IS patients with noncarotid pathogenesis were excluded, yielding 78 study patients (38 men and 40 women with a mean age of 64.3 years, SD 14.7) with 156 paired watershed vessel/cerebral hemisphere observations. Thirty-seven patients had 40 TIA/IS events. There was a significant association between type VI plaque (demonstrating cap rupture, hemorrhage, and/or thrombosis) and ipsilateral TIA/IS (P<0.001). A multiple logistic regression model including standard Framingham risk factors and type VI plaque was constructed. Type VI plaque was the dominant outcome-associated observation achieving significance (P<0.0001; odds ratio, 11.66; 95% confidence interval, 5.31 to 25.60). Conclusions: In situ type VI carotid bifurcation region plaque identified by magnetic resonance imaging is associated with ipsilateral acute TIA/IS as an independent identifier of events, thereby supporting the dominant disease pathophysiology.

Original languageEnglish (US)
Pages (from-to)2031-2038
Number of pages8
JournalCirculation
Volume122
Issue number20
DOIs
StatePublished - Nov 16 2010
Externally publishedYes

Fingerprint

Transient Ischemic Attack
Atherosclerotic Plaques
Stroke
Magnetic Resonance Imaging
Rupture
Logistic Models
Magnetic Resonance Angiography
Thromboembolism
Cerebrum
Observational Studies
Thrombosis
Odds Ratio
Observation
Confidence Intervals
Hemorrhage
Brain

Keywords

  • angiography
  • atherosclerosis
  • carotid arteries
  • magnetic resonance imaging
  • plaque
  • stenosis
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Parmar, J. P., Rogers, W. J., Mugler, J. P., Baskurt, E., Altes, T. A., Nandalur, K. R., ... Kramer, C. M. (2010). Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke. Circulation, 122(20), 2031-2038. https://doi.org/10.1161/CIRCULATIONAHA.109.866053

Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke. / Parmar, Jaywant P.; Rogers, Walter J.; Mugler, John P.; Baskurt, Erol; Altes, Talissa A.; Nandalur, Kiran R.; Stukenborg, George J.; Phillips, C. Douglas; Hagspiel, Klaus D.; Matsumoto, Alan H.; Dake, Michael D.; Kramer, Christopher M.

In: Circulation, Vol. 122, No. 20, 16.11.2010, p. 2031-2038.

Research output: Contribution to journalArticle

Parmar, JP, Rogers, WJ, Mugler, JP, Baskurt, E, Altes, TA, Nandalur, KR, Stukenborg, GJ, Phillips, CD, Hagspiel, KD, Matsumoto, AH, Dake, MD & Kramer, CM 2010, 'Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke', Circulation, vol. 122, no. 20, pp. 2031-2038. https://doi.org/10.1161/CIRCULATIONAHA.109.866053
Parmar, Jaywant P. ; Rogers, Walter J. ; Mugler, John P. ; Baskurt, Erol ; Altes, Talissa A. ; Nandalur, Kiran R. ; Stukenborg, George J. ; Phillips, C. Douglas ; Hagspiel, Klaus D. ; Matsumoto, Alan H. ; Dake, Michael D. ; Kramer, Christopher M. / Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke. In: Circulation. 2010 ; Vol. 122, No. 20. pp. 2031-2038.
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abstract = "Background: Carotid atherosclerotic plaque rupture is thought to cause transient ischemic attack (TIA) and ischemic stroke (IS). Pathological hallmarks of these plaques have been identified through observational studies. Although generally accepted, the relationship between cerebral thromboembolism and in situ atherosclerotic plaque morphology has never been directly observed noninvasively in the acute setting. Methods and Results: Consecutive acutely symptomatic patients referred for stroke protocol magnetic resonance imaging/angiography underwent additional T1- and T2-weighted carotid bifurcation imaging with the use of a 3-dimensional technique with blood signal suppression. Two blinded reviewers performed plaque gradings according to the American Heart Association classification system. Discharge outcomes and brain magnetic resonance imaging results were obtained. Image quality for plaque characterization was adequate in 86 of 106 patients (81{\%}). Eight TIA/IS patients with noncarotid pathogenesis were excluded, yielding 78 study patients (38 men and 40 women with a mean age of 64.3 years, SD 14.7) with 156 paired watershed vessel/cerebral hemisphere observations. Thirty-seven patients had 40 TIA/IS events. There was a significant association between type VI plaque (demonstrating cap rupture, hemorrhage, and/or thrombosis) and ipsilateral TIA/IS (P<0.001). A multiple logistic regression model including standard Framingham risk factors and type VI plaque was constructed. Type VI plaque was the dominant outcome-associated observation achieving significance (P<0.0001; odds ratio, 11.66; 95{\%} confidence interval, 5.31 to 25.60). Conclusions: In situ type VI carotid bifurcation region plaque identified by magnetic resonance imaging is associated with ipsilateral acute TIA/IS as an independent identifier of events, thereby supporting the dominant disease pathophysiology.",
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T1 - Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke

AU - Parmar, Jaywant P.

AU - Rogers, Walter J.

AU - Mugler, John P.

AU - Baskurt, Erol

AU - Altes, Talissa A.

AU - Nandalur, Kiran R.

AU - Stukenborg, George J.

AU - Phillips, C. Douglas

AU - Hagspiel, Klaus D.

AU - Matsumoto, Alan H.

AU - Dake, Michael D.

AU - Kramer, Christopher M.

PY - 2010/11/16

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N2 - Background: Carotid atherosclerotic plaque rupture is thought to cause transient ischemic attack (TIA) and ischemic stroke (IS). Pathological hallmarks of these plaques have been identified through observational studies. Although generally accepted, the relationship between cerebral thromboembolism and in situ atherosclerotic plaque morphology has never been directly observed noninvasively in the acute setting. Methods and Results: Consecutive acutely symptomatic patients referred for stroke protocol magnetic resonance imaging/angiography underwent additional T1- and T2-weighted carotid bifurcation imaging with the use of a 3-dimensional technique with blood signal suppression. Two blinded reviewers performed plaque gradings according to the American Heart Association classification system. Discharge outcomes and brain magnetic resonance imaging results were obtained. Image quality for plaque characterization was adequate in 86 of 106 patients (81%). Eight TIA/IS patients with noncarotid pathogenesis were excluded, yielding 78 study patients (38 men and 40 women with a mean age of 64.3 years, SD 14.7) with 156 paired watershed vessel/cerebral hemisphere observations. Thirty-seven patients had 40 TIA/IS events. There was a significant association between type VI plaque (demonstrating cap rupture, hemorrhage, and/or thrombosis) and ipsilateral TIA/IS (P<0.001). A multiple logistic regression model including standard Framingham risk factors and type VI plaque was constructed. Type VI plaque was the dominant outcome-associated observation achieving significance (P<0.0001; odds ratio, 11.66; 95% confidence interval, 5.31 to 25.60). Conclusions: In situ type VI carotid bifurcation region plaque identified by magnetic resonance imaging is associated with ipsilateral acute TIA/IS as an independent identifier of events, thereby supporting the dominant disease pathophysiology.

AB - Background: Carotid atherosclerotic plaque rupture is thought to cause transient ischemic attack (TIA) and ischemic stroke (IS). Pathological hallmarks of these plaques have been identified through observational studies. Although generally accepted, the relationship between cerebral thromboembolism and in situ atherosclerotic plaque morphology has never been directly observed noninvasively in the acute setting. Methods and Results: Consecutive acutely symptomatic patients referred for stroke protocol magnetic resonance imaging/angiography underwent additional T1- and T2-weighted carotid bifurcation imaging with the use of a 3-dimensional technique with blood signal suppression. Two blinded reviewers performed plaque gradings according to the American Heart Association classification system. Discharge outcomes and brain magnetic resonance imaging results were obtained. Image quality for plaque characterization was adequate in 86 of 106 patients (81%). Eight TIA/IS patients with noncarotid pathogenesis were excluded, yielding 78 study patients (38 men and 40 women with a mean age of 64.3 years, SD 14.7) with 156 paired watershed vessel/cerebral hemisphere observations. Thirty-seven patients had 40 TIA/IS events. There was a significant association between type VI plaque (demonstrating cap rupture, hemorrhage, and/or thrombosis) and ipsilateral TIA/IS (P<0.001). A multiple logistic regression model including standard Framingham risk factors and type VI plaque was constructed. Type VI plaque was the dominant outcome-associated observation achieving significance (P<0.0001; odds ratio, 11.66; 95% confidence interval, 5.31 to 25.60). Conclusions: In situ type VI carotid bifurcation region plaque identified by magnetic resonance imaging is associated with ipsilateral acute TIA/IS as an independent identifier of events, thereby supporting the dominant disease pathophysiology.

KW - angiography

KW - atherosclerosis

KW - carotid arteries

KW - magnetic resonance imaging

KW - plaque

KW - stenosis

KW - stroke

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