Magnetization transfer contrast imaging in Niemann pick type C mouse liver

Jingyu Guo, Robert Erickson, Theodore "Ted" Trouard, Jean-Philippe Galons, Robert Gillies

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To investigate livers of mice afflicted with Niemann Pick type C (NP-C) disease using magnetization transfer contrast (MTC) imaging and to test the hypothesis that the MT ratio reproducibly changes during disease progression. Background: NP-C is a heritable defect of lipid metabolism that results in the accumulation of unesterified cholesterol and gangliosides in virtually all cells. Symptoms predominate in brain and liver, which have high endogenous rates of lipid turnover. It is fatal to children, usually early in the second decade of life. Previous work has shown that the efficiency of magnetization transfer (MT) can be affected by cholesterol and collagen in tissues. The MT ratio (MTR) was calculated and compared during growth and therapy of diseased and control mice. Results: Significant differences in the MTR were observed between livers of diseased and control mice. These ratios were consistent with collagen deposition associated with fibrosis, and not the accumulation of unesterified cholesterol in this organ. Conclusion: These results indicate that MTC imaging may have clinical potential for monitoring progression and therapy in NP-C disease.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume18
Issue number3
DOIs
StatePublished - Sep 1 2003

Fingerprint

Type C Niemann-Pick Disease
Cholesterol
Magnetic Resonance Imaging
Liver
Collagen
Gangliosides
Lipid Metabolism
Disease Progression
Liver Diseases
Fibrosis
Lipids
Brain
Therapeutics
Growth

Keywords

  • Cholesterol metabolism
  • Collagen deposition
  • Liver fibrosis
  • Magnetization transfer
  • Niemann Pick type C disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetization transfer contrast imaging in Niemann pick type C mouse liver. / Guo, Jingyu; Erickson, Robert; Trouard, Theodore "Ted"; Galons, Jean-Philippe; Gillies, Robert.

In: Journal of Magnetic Resonance Imaging, Vol. 18, No. 3, 01.09.2003, p. 321-327.

Research output: Contribution to journalArticle

@article{6ea6c66834384a65a8ddf08f484fa5d4,
title = "Magnetization transfer contrast imaging in Niemann pick type C mouse liver",
abstract = "Purpose: To investigate livers of mice afflicted with Niemann Pick type C (NP-C) disease using magnetization transfer contrast (MTC) imaging and to test the hypothesis that the MT ratio reproducibly changes during disease progression. Background: NP-C is a heritable defect of lipid metabolism that results in the accumulation of unesterified cholesterol and gangliosides in virtually all cells. Symptoms predominate in brain and liver, which have high endogenous rates of lipid turnover. It is fatal to children, usually early in the second decade of life. Previous work has shown that the efficiency of magnetization transfer (MT) can be affected by cholesterol and collagen in tissues. The MT ratio (MTR) was calculated and compared during growth and therapy of diseased and control mice. Results: Significant differences in the MTR were observed between livers of diseased and control mice. These ratios were consistent with collagen deposition associated with fibrosis, and not the accumulation of unesterified cholesterol in this organ. Conclusion: These results indicate that MTC imaging may have clinical potential for monitoring progression and therapy in NP-C disease.",
keywords = "Cholesterol metabolism, Collagen deposition, Liver fibrosis, Magnetization transfer, Niemann Pick type C disease",
author = "Jingyu Guo and Robert Erickson and Trouard, {Theodore {"}Ted{"}} and Jean-Philippe Galons and Robert Gillies",
year = "2003",
month = "9",
day = "1",
doi = "10.1002/jmri.10404",
language = "English (US)",
volume = "18",
pages = "321--327",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Magnetization transfer contrast imaging in Niemann pick type C mouse liver

AU - Guo, Jingyu

AU - Erickson, Robert

AU - Trouard, Theodore "Ted"

AU - Galons, Jean-Philippe

AU - Gillies, Robert

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Purpose: To investigate livers of mice afflicted with Niemann Pick type C (NP-C) disease using magnetization transfer contrast (MTC) imaging and to test the hypothesis that the MT ratio reproducibly changes during disease progression. Background: NP-C is a heritable defect of lipid metabolism that results in the accumulation of unesterified cholesterol and gangliosides in virtually all cells. Symptoms predominate in brain and liver, which have high endogenous rates of lipid turnover. It is fatal to children, usually early in the second decade of life. Previous work has shown that the efficiency of magnetization transfer (MT) can be affected by cholesterol and collagen in tissues. The MT ratio (MTR) was calculated and compared during growth and therapy of diseased and control mice. Results: Significant differences in the MTR were observed between livers of diseased and control mice. These ratios were consistent with collagen deposition associated with fibrosis, and not the accumulation of unesterified cholesterol in this organ. Conclusion: These results indicate that MTC imaging may have clinical potential for monitoring progression and therapy in NP-C disease.

AB - Purpose: To investigate livers of mice afflicted with Niemann Pick type C (NP-C) disease using magnetization transfer contrast (MTC) imaging and to test the hypothesis that the MT ratio reproducibly changes during disease progression. Background: NP-C is a heritable defect of lipid metabolism that results in the accumulation of unesterified cholesterol and gangliosides in virtually all cells. Symptoms predominate in brain and liver, which have high endogenous rates of lipid turnover. It is fatal to children, usually early in the second decade of life. Previous work has shown that the efficiency of magnetization transfer (MT) can be affected by cholesterol and collagen in tissues. The MT ratio (MTR) was calculated and compared during growth and therapy of diseased and control mice. Results: Significant differences in the MTR were observed between livers of diseased and control mice. These ratios were consistent with collagen deposition associated with fibrosis, and not the accumulation of unesterified cholesterol in this organ. Conclusion: These results indicate that MTC imaging may have clinical potential for monitoring progression and therapy in NP-C disease.

KW - Cholesterol metabolism

KW - Collagen deposition

KW - Liver fibrosis

KW - Magnetization transfer

KW - Niemann Pick type C disease

UR - http://www.scopus.com/inward/record.url?scp=0042328214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042328214&partnerID=8YFLogxK

U2 - 10.1002/jmri.10404

DO - 10.1002/jmri.10404

M3 - Article

VL - 18

SP - 321

EP - 327

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 3

ER -