Major depression drives severity of American urological association symptom index

Timothy V. Johnson, Ammara Abbasi, Samantha S. Ehrlich, Renee S. Kleris, Siri L. Chirumamilla, Evan D. Schoenberg, Ashli Owen-Smith, Charles L Raison, Viraj A. Master

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives: To evaluate the unclear relationship between depression and benign prostatic hyperplasia (BPH) by assessing depression's effect on the American Urological Association Symptom Index (AUA-SI) scores. Depression is a common illness associated with chronic inflammatory disease states. Data have suggested a significant role of inflammation in the progression of BPH. Methods: The present prospective study involved 547 male patients who completed the Geriatric Depression Scale and the AUA-SI. We evaluated whether the mean AUA-SI score and the severity categories differed by the state of depression. We then conducted binary logistic regression analysis with forward stepwise regression to assess the relationship between depression and the severity symptoms as determined by the AUA-SI score. Results: Of the cohort, 22% screened positive for depressive symptoms. The depressed patients (Geriatric Depression Scale score >5) reported significantly more severe symptoms (mean AUA-SI score 16.61 ± 9.89) compared with the nondepressed patients (Geriatric Depression Scale score of ≤5 and mean AUA-SI score 10.65 ± 7.29; F = 40.19, P <.001). After controlling for socioeconomic and demographic variables, depressed patients were 3 times more likely to present with severe symptoms (odds ratio 3.079, 95% confidence interval 1.129-8.402, P = .028). Conclusions: A significant association was found between depression and BPH. However, it remains unclear whether this relationship represents unidirectional or bidirectional causality. Additional research is imperative to assess the nature of this correlation, either to address comorbid depression in patients with BPH or to ensure that depressed patients do not report falsely elevated symptoms.

Original languageEnglish (US)
Pages (from-to)1317-1320
Number of pages4
JournalUrology
Volume76
Issue number6
DOIs
StatePublished - Dec 2010
Externally publishedYes

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Depression
Prostatic Hyperplasia
Geriatrics
Drive
Causality
Chronic Disease
Logistic Models
Odds Ratio
Regression Analysis
Demography
Prospective Studies
Confidence Intervals
Inflammation
Research

ASJC Scopus subject areas

  • Urology

Cite this

Johnson, T. V., Abbasi, A., Ehrlich, S. S., Kleris, R. S., Chirumamilla, S. L., Schoenberg, E. D., ... Master, V. A. (2010). Major depression drives severity of American urological association symptom index. Urology, 76(6), 1317-1320. https://doi.org/10.1016/j.urology.2010.01.069

Major depression drives severity of American urological association symptom index. / Johnson, Timothy V.; Abbasi, Ammara; Ehrlich, Samantha S.; Kleris, Renee S.; Chirumamilla, Siri L.; Schoenberg, Evan D.; Owen-Smith, Ashli; Raison, Charles L; Master, Viraj A.

In: Urology, Vol. 76, No. 6, 12.2010, p. 1317-1320.

Research output: Contribution to journalArticle

Johnson, TV, Abbasi, A, Ehrlich, SS, Kleris, RS, Chirumamilla, SL, Schoenberg, ED, Owen-Smith, A, Raison, CL & Master, VA 2010, 'Major depression drives severity of American urological association symptom index', Urology, vol. 76, no. 6, pp. 1317-1320. https://doi.org/10.1016/j.urology.2010.01.069
Johnson TV, Abbasi A, Ehrlich SS, Kleris RS, Chirumamilla SL, Schoenberg ED et al. Major depression drives severity of American urological association symptom index. Urology. 2010 Dec;76(6):1317-1320. https://doi.org/10.1016/j.urology.2010.01.069
Johnson, Timothy V. ; Abbasi, Ammara ; Ehrlich, Samantha S. ; Kleris, Renee S. ; Chirumamilla, Siri L. ; Schoenberg, Evan D. ; Owen-Smith, Ashli ; Raison, Charles L ; Master, Viraj A. / Major depression drives severity of American urological association symptom index. In: Urology. 2010 ; Vol. 76, No. 6. pp. 1317-1320.
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abstract = "Objectives: To evaluate the unclear relationship between depression and benign prostatic hyperplasia (BPH) by assessing depression's effect on the American Urological Association Symptom Index (AUA-SI) scores. Depression is a common illness associated with chronic inflammatory disease states. Data have suggested a significant role of inflammation in the progression of BPH. Methods: The present prospective study involved 547 male patients who completed the Geriatric Depression Scale and the AUA-SI. We evaluated whether the mean AUA-SI score and the severity categories differed by the state of depression. We then conducted binary logistic regression analysis with forward stepwise regression to assess the relationship between depression and the severity symptoms as determined by the AUA-SI score. Results: Of the cohort, 22{\%} screened positive for depressive symptoms. The depressed patients (Geriatric Depression Scale score >5) reported significantly more severe symptoms (mean AUA-SI score 16.61 ± 9.89) compared with the nondepressed patients (Geriatric Depression Scale score of ≤5 and mean AUA-SI score 10.65 ± 7.29; F = 40.19, P <.001). After controlling for socioeconomic and demographic variables, depressed patients were 3 times more likely to present with severe symptoms (odds ratio 3.079, 95{\%} confidence interval 1.129-8.402, P = .028). Conclusions: A significant association was found between depression and BPH. However, it remains unclear whether this relationship represents unidirectional or bidirectional causality. Additional research is imperative to assess the nature of this correlation, either to address comorbid depression in patients with BPH or to ensure that depressed patients do not report falsely elevated symptoms.",
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AU - Chirumamilla, Siri L.

AU - Schoenberg, Evan D.

AU - Owen-Smith, Ashli

AU - Raison, Charles L

AU - Master, Viraj A.

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