Major limitations of randomized clinical trials involving coronary artery bifurcation interventions

Time for redesigning clinical trials by involving only true bifurcation lesions and using appropriate bifurcation classification

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14 Citations (Scopus)

Abstract

Coronary bifurcation lesion intervention is technically challenging with higher complication rates. Many coronary interventional trials have been conducted involving coronary bifurcation lesions in order to compare one-stent with two-stent techniques. However, these trials have major limitation by enrolling all bifurcation lesions, including low-risk lesions so-called not true bifurcation lesions. This manuscript discusses the importance of appropriate designing of clinical trials for evaluation of complex techniques in coronary bifurcation lesions.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalJournal of Interventional Cardiology
Volume24
Issue number4
DOIs
StatePublished - Aug 2011

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Stents
Coronary Vessels
Randomized Controlled Trials
Clinical Trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Major limitations of randomized clinical trials involving coronary artery bifurcation interventions: Time for redesigning clinical trials by involving only true bifurcation lesions and using appropriate bifurcation classification",
abstract = "Coronary bifurcation lesion intervention is technically challenging with higher complication rates. Many coronary interventional trials have been conducted involving coronary bifurcation lesions in order to compare one-stent with two-stent techniques. However, these trials have major limitation by enrolling all bifurcation lesions, including low-risk lesions so-called not true bifurcation lesions. This manuscript discusses the importance of appropriate designing of clinical trials for evaluation of complex techniques in coronary bifurcation lesions.",
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