Making microvascular networks work: Angiogenesis, Remodeling, And pruning

Axel R. Pries, Timothy W. Secomb

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

The adequate and efficient functioning of the microcirculation requires not only numerous vessels providing a large surface area for transport but also a structure that provides short diffusion distances from capillaries to tissue and efficient distribution of convective blood flow. Theoretical models show how a combination of angiogenesis, remodeling, and pruning in response to hemodynamic and metabolic stimuli, termed “angioadaptation,” generates well organized, functional networks.

Original languageEnglish (US)
Pages (from-to)446-455
Number of pages10
JournalPhysiology
Volume29
Issue number6
DOIs
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Physiology

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