Making sense of G-quadruplex and i-motif functions in oncogene promoters

Tracy A. Brooks, Samantha Kendrick, Laurence Hurley

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

The presence and biological importance of DNA secondary structures in eukaryotic promoters are becoming increasingly recognized among chemists and biologists as bioinformatics in vitro and in vivo evidence for these structures in the c-Myc, c-Kit, KRAS, PDGF-A, hTERT, Rb, RET and Hif-1 promoters accumulates. Nevertheless, the evidence remains largely circumstantial. This minireview differs from previous ones in that here we examine the diversity of G-quadruplex and i-motif structures in promoter elements and attempt to categorize the different types of arrangements in which they are found. For the c-Myc G-quadruplex and Bcl-2 i-motif, we summarize recent biological and structural studies.

Original languageEnglish (US)
Pages (from-to)3459-3469
Number of pages11
JournalFEBS Journal
Volume277
Issue number17
DOIs
StatePublished - 2010

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G-Quadruplexes
Bioinformatics
Oncogenes
DNA
Computational Biology
platelet-derived growth factor A
In Vitro Techniques

Keywords

  • Bcl-2
  • c-Myc
  • DNA secondary structures
  • G-quadruplex
  • gene expression
  • i-motif
  • NM23-H2
  • nucleolin
  • promoter
  • supercoiling

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Making sense of G-quadruplex and i-motif functions in oncogene promoters. / Brooks, Tracy A.; Kendrick, Samantha; Hurley, Laurence.

In: FEBS Journal, Vol. 277, No. 17, 2010, p. 3459-3469.

Research output: Contribution to journalArticle

Brooks, Tracy A. ; Kendrick, Samantha ; Hurley, Laurence. / Making sense of G-quadruplex and i-motif functions in oncogene promoters. In: FEBS Journal. 2010 ; Vol. 277, No. 17. pp. 3459-3469.
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