Making the most of metal ions

N. C. Horton, J. J. Perona

Research output: Contribution to journalShort survey

43 Scopus citations


Crystal structures of the homing endonuclease I-CreI bound to substrate DNA and divalent metals show that one metal ion is shared between the two active sites of the enzyme. This arrangement appears uniquely suited to the formation of double-stranded DNA breaks via a concerted reaction.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalNature Structural Biology
Issue number4
StatePublished - Apr 18 2001
Externally publishedYes


ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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