Making the most of metal ions

N. C. Horton, J. J. Perona

Research output: Contribution to journalShort surveypeer-review

43 Scopus citations

Abstract

Crystal structures of the homing endonuclease I-CreI bound to substrate DNA and divalent metals show that one metal ion is shared between the two active sites of the enzyme. This arrangement appears uniquely suited to the formation of double-stranded DNA breaks via a concerted reaction.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalNature Structural Biology
Volume8
Issue number4
DOIs
StatePublished - Apr 18 2001
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

Fingerprint Dive into the research topics of 'Making the most of metal ions'. Together they form a unique fingerprint.

Cite this