Making the most of metal ions

Nancy C Horton, J. J. Perona

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Crystal structures of the homing endonuclease I-CreI bound to substrate DNA and divalent metals show that one metal ion is shared between the two active sites of the enzyme. This arrangement appears uniquely suited to the formation of double-stranded DNA breaks via a concerted reaction.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalNature Structural Biology
Volume8
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Metal ions
Metals
Ions
Double-Stranded DNA Breaks
Deoxyribonuclease I
DNA
Catalytic Domain
Crystal structure
Substrates
Enzymes
endodeoxyribonuclease CreI

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

Cite this

Making the most of metal ions. / Horton, Nancy C; Perona, J. J.

In: Nature Structural Biology, Vol. 8, No. 4, 2001, p. 290-293.

Research output: Contribution to journalArticle

Horton, Nancy C ; Perona, J. J. / Making the most of metal ions. In: Nature Structural Biology. 2001 ; Vol. 8, No. 4. pp. 290-293.
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