Management of early endometrial carcinoma

L. J.Sant Cassia, Burkhard Weppelmann, Hugh Shingleton, S. J. Soong, Kenneth Hatch, Merle M. Salter

Research output: Contribution to journalArticle

24 Scopus citations


Management of early endometrial carcinoma is controversial in regard to timing and indication of adjunctive radiation therapy. Two hundred eighty patients with stage I carcinoma of the endometrium are analyzed: 135 patients were treated with surgery only and 61 patients underwent preoperative and 83 patients postoperative radiation therapy. The overall survival was 94%. Recurrence rates in all three treatment arms were equal. Tumor grade was found to change from the diagnostic D&C specimen to the definite surgical specimen in 31% of all cases and in 50% of all grade 3 lesions. As only 39% of all patients required post-operative radiation therapy with equal survival, a primary surgical approach spares the majority of patient unnecessary treatment and preserves prognostically important histology.

Original languageEnglish (US)
Pages (from-to)362-366
Number of pages5
JournalGynecologic oncology
Issue number3
StatePublished - Dec 1989
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Cassia, L. J. S., Weppelmann, B., Shingleton, H., Soong, S. J., Hatch, K., & Salter, M. M. (1989). Management of early endometrial carcinoma. Gynecologic oncology, 35(3), 362-366.