Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21→q22

J. D. Knox, D. R. Boreham, J. A. Walker, D. P. Morrison, L. M. Matrisian, R. B. Nagle, G. T. Bowden

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The matrix metalloproteinase, matrilysin, is thought to play an important role in the early steps of tumor progression. We determined the chromosome location of the matrilysin gene (MMP7) by Southern and PCR analysis of two different panels of somatic cell hybrids and in situ hybridization of metaphase chromosomes. Matrilysin maps to the region, 11q21→q22, adding MMP7 to the cluster of matrix metalloproteinase genes that have already mapped to this region.

Original languageEnglish (US)
Pages (from-to)179-182
Number of pages4
JournalCytogenetic and Genome Research
Volume72
Issue number2-3
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Knox, J. D., Boreham, D. R., Walker, J. A., Morrison, D. P., Matrisian, L. M., Nagle, R. B., & Bowden, G. T. (1996). Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21→q22. Cytogenetic and Genome Research, 72(2-3), 179-182. https://doi.org/10.1159/000134181