Mapping the ECG in the live rabbit heart using Ultrasound current source density imaging with coded excitation

Yexian Qin, Qian Li, Pier Ingram, Russell S Witte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Ultrasound current source density imaging (UCSDI) is a noninvasive technique for mapping electric current fields in 4D (space + time) with the resolution of ultrasound imaging. This approach can potentially overcome limitations of conventional electrical mapping procedures often used during treatment of cardiac arrhythmia or epilepsy. However, at physiologic currents, the detected acoustoelectric (AE) interaction signal in tissue is very weak. In this work, we evaluated coded ultrasound excitation (chirps) for improving the sensitivity of UCSDI for mapping the electrocardiogram (ECG) in a live rabbit heart preparation. Results confirmed that chirps improved detection of the AE signal by as much as 6.1 dB compared to a square pulse. We further demonstrated mapping the ECG using a clinical intracardiac catheter, 1 MHz ultrasound transducer and coded excitation. B-mode pulse echo and UCSDI revealed regions of high current flow in the heart wall during the peak of the ECG. These improvements to UCSDI are important steps towards translation of this new technology to the clinic for rapidly mapping the cardiac activation wave.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
Pages910-913
Number of pages4
DOIs
StatePublished - 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Fingerprint

electrocardiography
rabbits
excitation
chirp
epilepsy
arrhythmia
pulses
electric current
high current
echoes
transducers
activation
preparation
sensitivity
interactions

Keywords

  • acoustoelectric
  • cardiac arrhythmia mapping
  • coded excitation chirps
  • ECG

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Qin, Y., Li, Q., Ingram, P., & Witte, R. S. (2012). Mapping the ECG in the live rabbit heart using Ultrasound current source density imaging with coded excitation. In IEEE International Ultrasonics Symposium, IUS (pp. 910-913). [6562471] https://doi.org/10.1109/ULTSYM.2012.0227

Mapping the ECG in the live rabbit heart using Ultrasound current source density imaging with coded excitation. / Qin, Yexian; Li, Qian; Ingram, Pier; Witte, Russell S.

IEEE International Ultrasonics Symposium, IUS. 2012. p. 910-913 6562471.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Qin, Y, Li, Q, Ingram, P & Witte, RS 2012, Mapping the ECG in the live rabbit heart using Ultrasound current source density imaging with coded excitation. in IEEE International Ultrasonics Symposium, IUS., 6562471, pp. 910-913, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 10/7/12. https://doi.org/10.1109/ULTSYM.2012.0227
Qin, Yexian ; Li, Qian ; Ingram, Pier ; Witte, Russell S. / Mapping the ECG in the live rabbit heart using Ultrasound current source density imaging with coded excitation. IEEE International Ultrasonics Symposium, IUS. 2012. pp. 910-913
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