Maps, Codes, and Sequence Elements: Can We Predict the Protein Output from an Alternatively Spliced Locus?

Shalini Sharma, Douglas L. Black

Research output: Contribution to journalShort survey

10 Scopus citations

Abstract

Alternative splicing choices are governed by splicing regulatory protein interactions with splicing silencer and enhancer elements present in the pre-mRNA. However, the prediction of these choices from genomic sequence is difficult, in part because the regulators can act as either enhancers or silencers. A recent study describes how for a particular neuronal splicing regulatory protein, Nova, the location of its binding sites is highly predictive of the protein's effect on an exon's splicing.

Original languageEnglish (US)
Pages (from-to)574-576
Number of pages3
JournalNeuron
Volume52
Issue number4
DOIs
StatePublished - Nov 22 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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