Marine fatty acid intake is associated with breast cancer prognosis

Ruth E. Patterson, Shirley W. Flatt, Vicky A. Newman, Loki Natarajan, Cheryl L. Rock, Cynthia Thomson, Bette J. Caan, Barbara A. Parker, John P. Pierce

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

EPA and DHA, long-chain (n-3) PUFA largely obtained from fish, inhibit the proliferation of breast cancer cells in vitro and reduce the initiation and progression of breast tumors in laboratory animals. Our purpose in this analysis was to examine whether intake of these marine fatty acids (EPA and DHA) were associated with prognosis in a cohort of women who had been diagnosed and treated for early stage breast cancer (n = 3,081). Median follow-up was 7.3 y. Dietary intake was assessed using 24-h recalls (∼4 recalls per dietary assessment obtained at 7 time points over 6 y). Survival models with time-dependent covariates were used to examine the association of repeated measures of dietary intake of EPA and DHA from food (i.e., marine sources) and supplements with disease-free survival and overall survival. Women with higher intakes of EPA and DHA from food had an approximate 25% reduced risk of additional breast cancer events [tertile 2: HR = 0.74 (95% CI = 0.58-0.94); tertile 3: HR = 0.72 (95% CI = 0.57-0.90)] compared with the lowest tertile of intake. Women with higher intakes of EPA and DHA from food had a dose-dependent reduced risk of all-cause mortality [tertile 2: HR = 0.75 (95% CI = 0.55-1.04); tertile 3: HR = 0.59 (95% CI = 0.43-0.82)]. EPA and DHA intake from fish oil supplements was not associated with breast cancer outcomes. The investigation indicates that marine fatty acids from food are associated with reduced risk of additional breast cancer events and all-cause mortality.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalJournal of Nutrition
Volume141
Issue number2
DOIs
StatePublished - Feb 1 2011

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Fatty Acids
Breast Neoplasms
Food
Survival
Mortality
Fish Oils
Omega-3 Fatty Acids
Laboratory Animals
Disease-Free Survival
Fishes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Patterson, R. E., Flatt, S. W., Newman, V. A., Natarajan, L., Rock, C. L., Thomson, C., ... Pierce, J. P. (2011). Marine fatty acid intake is associated with breast cancer prognosis. Journal of Nutrition, 141(2), 201-206. https://doi.org/10.3945/jn.110.128777

Marine fatty acid intake is associated with breast cancer prognosis. / Patterson, Ruth E.; Flatt, Shirley W.; Newman, Vicky A.; Natarajan, Loki; Rock, Cheryl L.; Thomson, Cynthia; Caan, Bette J.; Parker, Barbara A.; Pierce, John P.

In: Journal of Nutrition, Vol. 141, No. 2, 01.02.2011, p. 201-206.

Research output: Contribution to journalArticle

Patterson, RE, Flatt, SW, Newman, VA, Natarajan, L, Rock, CL, Thomson, C, Caan, BJ, Parker, BA & Pierce, JP 2011, 'Marine fatty acid intake is associated with breast cancer prognosis', Journal of Nutrition, vol. 141, no. 2, pp. 201-206. https://doi.org/10.3945/jn.110.128777
Patterson RE, Flatt SW, Newman VA, Natarajan L, Rock CL, Thomson C et al. Marine fatty acid intake is associated with breast cancer prognosis. Journal of Nutrition. 2011 Feb 1;141(2):201-206. https://doi.org/10.3945/jn.110.128777
Patterson, Ruth E. ; Flatt, Shirley W. ; Newman, Vicky A. ; Natarajan, Loki ; Rock, Cheryl L. ; Thomson, Cynthia ; Caan, Bette J. ; Parker, Barbara A. ; Pierce, John P. / Marine fatty acid intake is associated with breast cancer prognosis. In: Journal of Nutrition. 2011 ; Vol. 141, No. 2. pp. 201-206.
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