Marriage protects men from clinically meaningful elevations in c-reactive protein

Results from the national social life, health, and aging project (NSHAP)

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective: To examine the association between marital status and C-reactive protein (CRP) levels after accounting for a range of relevant of demographic, subjective, and objective health indicators and psychological variables. Minor elevations in CRP (>3 mg/L) are a nonspecific marker of systemic inflammation and predict the future onset of cardiovascular disease. METHODS:: Data from the National Social Life, Health, and Aging Project (NSHAP), a population-based study of community-dwelling older adults in the United States, were used to study CRP elevations. Home-based interviews were conducted with the entire NSHAP sample, a subset of whom provided whole blood samples for the CRP analyses. The final sample consisted of 1715 participants (n = 838 men) with an average age of 69.51 years. Multiple and logistic regression analyses were conducted, using CRP as a continuous and dichotomous outcome variable. RESULTS:: Across the entire NSHAP sample, married men demonstrated the lowest levels of CRP. After adjusting for the competing predictors, marriage remained a unique protective factor against elevated CRP for men (odds ratio = 0.56, 95% Confidence Interval = 0.39-0.79). The absolute risk reduction (for being classified in the high-risk CRP group) associated with being a married man was roughly equivalent to that observed for adults who were normotensive, nonsmokers, and those with a normal body mass index. CONCLUSIONS:: Remaining married in late adulthood affords men unique and robust protection against elevated levels of CRP. The findings are discussed in terms of the pathways linking marital status and health outcomes among older adults.

Original languageEnglish (US)
Pages (from-to)828-835
Number of pages8
JournalPsychosomatic Medicine
Volume71
Issue number8
DOIs
StatePublished - Oct 2009

Fingerprint

Marriage
C-Reactive Protein
Health
Proteins
Marital Status
Independent Living
Numbers Needed To Treat
Diagnostic Self Evaluation
Body Mass Index
Cardiovascular Diseases
Logistic Models
Odds Ratio
Regression Analysis
Demography
Confidence Intervals
Interviews
Psychology
Inflammation
Population

Keywords

  • Aging.
  • C-reactive protein
  • Inflammation
  • Marital status
  • Risk reduction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology

Cite this

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title = "Marriage protects men from clinically meaningful elevations in c-reactive protein: Results from the national social life, health, and aging project (NSHAP)",
abstract = "Objective: To examine the association between marital status and C-reactive protein (CRP) levels after accounting for a range of relevant of demographic, subjective, and objective health indicators and psychological variables. Minor elevations in CRP (>3 mg/L) are a nonspecific marker of systemic inflammation and predict the future onset of cardiovascular disease. METHODS:: Data from the National Social Life, Health, and Aging Project (NSHAP), a population-based study of community-dwelling older adults in the United States, were used to study CRP elevations. Home-based interviews were conducted with the entire NSHAP sample, a subset of whom provided whole blood samples for the CRP analyses. The final sample consisted of 1715 participants (n = 838 men) with an average age of 69.51 years. Multiple and logistic regression analyses were conducted, using CRP as a continuous and dichotomous outcome variable. RESULTS:: Across the entire NSHAP sample, married men demonstrated the lowest levels of CRP. After adjusting for the competing predictors, marriage remained a unique protective factor against elevated CRP for men (odds ratio = 0.56, 95{\%} Confidence Interval = 0.39-0.79). The absolute risk reduction (for being classified in the high-risk CRP group) associated with being a married man was roughly equivalent to that observed for adults who were normotensive, nonsmokers, and those with a normal body mass index. CONCLUSIONS:: Remaining married in late adulthood affords men unique and robust protection against elevated levels of CRP. The findings are discussed in terms of the pathways linking marital status and health outcomes among older adults.",
keywords = "Aging., C-reactive protein, Inflammation, Marital status, Risk reduction",
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N2 - Objective: To examine the association between marital status and C-reactive protein (CRP) levels after accounting for a range of relevant of demographic, subjective, and objective health indicators and psychological variables. Minor elevations in CRP (>3 mg/L) are a nonspecific marker of systemic inflammation and predict the future onset of cardiovascular disease. METHODS:: Data from the National Social Life, Health, and Aging Project (NSHAP), a population-based study of community-dwelling older adults in the United States, were used to study CRP elevations. Home-based interviews were conducted with the entire NSHAP sample, a subset of whom provided whole blood samples for the CRP analyses. The final sample consisted of 1715 participants (n = 838 men) with an average age of 69.51 years. Multiple and logistic regression analyses were conducted, using CRP as a continuous and dichotomous outcome variable. RESULTS:: Across the entire NSHAP sample, married men demonstrated the lowest levels of CRP. After adjusting for the competing predictors, marriage remained a unique protective factor against elevated CRP for men (odds ratio = 0.56, 95% Confidence Interval = 0.39-0.79). The absolute risk reduction (for being classified in the high-risk CRP group) associated with being a married man was roughly equivalent to that observed for adults who were normotensive, nonsmokers, and those with a normal body mass index. CONCLUSIONS:: Remaining married in late adulthood affords men unique and robust protection against elevated levels of CRP. The findings are discussed in terms of the pathways linking marital status and health outcomes among older adults.

AB - Objective: To examine the association between marital status and C-reactive protein (CRP) levels after accounting for a range of relevant of demographic, subjective, and objective health indicators and psychological variables. Minor elevations in CRP (>3 mg/L) are a nonspecific marker of systemic inflammation and predict the future onset of cardiovascular disease. METHODS:: Data from the National Social Life, Health, and Aging Project (NSHAP), a population-based study of community-dwelling older adults in the United States, were used to study CRP elevations. Home-based interviews were conducted with the entire NSHAP sample, a subset of whom provided whole blood samples for the CRP analyses. The final sample consisted of 1715 participants (n = 838 men) with an average age of 69.51 years. Multiple and logistic regression analyses were conducted, using CRP as a continuous and dichotomous outcome variable. RESULTS:: Across the entire NSHAP sample, married men demonstrated the lowest levels of CRP. After adjusting for the competing predictors, marriage remained a unique protective factor against elevated CRP for men (odds ratio = 0.56, 95% Confidence Interval = 0.39-0.79). The absolute risk reduction (for being classified in the high-risk CRP group) associated with being a married man was roughly equivalent to that observed for adults who were normotensive, nonsmokers, and those with a normal body mass index. CONCLUSIONS:: Remaining married in late adulthood affords men unique and robust protection against elevated levels of CRP. The findings are discussed in terms of the pathways linking marital status and health outcomes among older adults.

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