Abstract
Perbenzoylated sialooligosaccharides were found to be stable derivatives, giving intense signals during the matrix-assisted laser desorption/ionization (MALDI) mass spectrometric analysis in the positive-ion mode. Terminal Neu5NAcα2→3 and α2→6Gal units of oligosaccharides undergo characteristic structural changes during benzoylation, yielding easily recognizable mass spectral patterns. Subpicomole carbohydrate samples were successfully benzoylated and analyzed through MALDI mass spectrometry.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4969-4973 |
| Number of pages | 5 |
| Journal | Analytical chemistry |
| Volume | 71 |
| Issue number | 21 |
| DOIs | |
| State | Published - Nov 1 1999 |
ASJC Scopus subject areas
- Analytical Chemistry
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Chen, P., Werner-Zwansiger, U., Wiesler, D., Pagel, M., & Novotny, M. V. (1999). Mass spectrometric analysis of benzoylated sialooligosaccharides and differentiation of terminal α2→3 and α2→6 sialogalactosylated linkages at subpicomole levels. Analytical chemistry, 71(21), 4969-4973. https://doi.org/10.1021/ac990674w