Maternal cytokine profiles during pregnancy predict asthma in children of mothers without asthma

Janet L Rothers, Debra A. Stern, I. Carla Lohman, Amber Spangenberg, Anne L Wright, Avery DeVries, Donata Vercelli, Marilyn Halonen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune Study, a nonselected birth cohort. Physician-diagnosed active asthma in children through age 9 and a history of asthma in their mothers were assessed through questionnaires. Maternal production of each of the cytokines IL-13, IL-4, IL-5, IFN-g, IL-10, and IL-17 during pregnancy was unrelated to childhood asthma. However, IFN-g/IL-13 and IFN-g/IL-4 ratios during pregnancy were associated with a decreased risk of childhood asthma (n = 381; odds ratio [OR], 0.33; 95% confidence interval [CI], 0.17–0.66; P = 0.002; and n = 368; OR, 0.36; 95% CI, 0.18–0.71; P = 0.003, respectively). The inverse relations of these two ratios with childhood asthma were only evident in mothers without asthma (n = 309; OR, 0.18; 95% CI, 0.08–0.42; P = 0.00007; and n = 299; OR, 0.17; 95% CI, 0.07–0.39; P = 0.00003, respectively) and not in mothers with asthma (n = 72 and 69, respectively; P for interaction by maternal asthma = 0.036 and 0.002, respectively). Paternal cytokine ratios were unrelated to childhood asthma. Maternal cytokine ratios in mothers without asthma were unrelated to the children’s skin-test reactivity, total IgE, physician-confirmed allergic rhinitis at age 5, or eczema in infancy. To our knowledge, this study provides the first evidence that cytokine profiles in pregnant mothers without asthma relate to the risk for childhood asthma, but not allergy, and suggests a process of asthma development that begins in utero and is independent of allergy.

Original languageEnglish (US)
Pages (from-to)592-600
Number of pages9
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume59
Issue number5
DOIs
StatePublished - Nov 1 2018

Fingerprint

Asthma
Mothers
Cytokines
Pregnancy
Allergies
Interleukin-13
Interleukin-4
Interleukin-17
Interleukin-5
Odds Ratio
Confidence Intervals
Mitogens
Interleukin-10
Immunoglobulin E
Skin
Blood
Hypersensitivity
Physicians
Eczema
Child Development

Keywords

  • Asthma
  • Children
  • Cytokines
  • Maternal
  • Pregnancy

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

Cite this

Maternal cytokine profiles during pregnancy predict asthma in children of mothers without asthma. / Rothers, Janet L; Stern, Debra A.; Lohman, I. Carla; Spangenberg, Amber; Wright, Anne L; DeVries, Avery; Vercelli, Donata; Halonen, Marilyn.

In: American Journal of Respiratory Cell and Molecular Biology, Vol. 59, No. 5, 01.11.2018, p. 592-600.

Research output: Contribution to journalArticle

Rothers, Janet L ; Stern, Debra A. ; Lohman, I. Carla ; Spangenberg, Amber ; Wright, Anne L ; DeVries, Avery ; Vercelli, Donata ; Halonen, Marilyn. / Maternal cytokine profiles during pregnancy predict asthma in children of mothers without asthma. In: American Journal of Respiratory Cell and Molecular Biology. 2018 ; Vol. 59, No. 5. pp. 592-600.
@article{b7d47b79fd934a59bcc11e3b303af22b,
title = "Maternal cytokine profiles during pregnancy predict asthma in children of mothers without asthma",
abstract = "Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune Study, a nonselected birth cohort. Physician-diagnosed active asthma in children through age 9 and a history of asthma in their mothers were assessed through questionnaires. Maternal production of each of the cytokines IL-13, IL-4, IL-5, IFN-g, IL-10, and IL-17 during pregnancy was unrelated to childhood asthma. However, IFN-g/IL-13 and IFN-g/IL-4 ratios during pregnancy were associated with a decreased risk of childhood asthma (n = 381; odds ratio [OR], 0.33; 95{\%} confidence interval [CI], 0.17–0.66; P = 0.002; and n = 368; OR, 0.36; 95{\%} CI, 0.18–0.71; P = 0.003, respectively). The inverse relations of these two ratios with childhood asthma were only evident in mothers without asthma (n = 309; OR, 0.18; 95{\%} CI, 0.08–0.42; P = 0.00007; and n = 299; OR, 0.17; 95{\%} CI, 0.07–0.39; P = 0.00003, respectively) and not in mothers with asthma (n = 72 and 69, respectively; P for interaction by maternal asthma = 0.036 and 0.002, respectively). Paternal cytokine ratios were unrelated to childhood asthma. Maternal cytokine ratios in mothers without asthma were unrelated to the children’s skin-test reactivity, total IgE, physician-confirmed allergic rhinitis at age 5, or eczema in infancy. To our knowledge, this study provides the first evidence that cytokine profiles in pregnant mothers without asthma relate to the risk for childhood asthma, but not allergy, and suggests a process of asthma development that begins in utero and is independent of allergy.",
keywords = "Asthma, Children, Cytokines, Maternal, Pregnancy",
author = "Rothers, {Janet L} and Stern, {Debra A.} and Lohman, {I. Carla} and Amber Spangenberg and Wright, {Anne L} and Avery DeVries and Donata Vercelli and Marilyn Halonen",
year = "2018",
month = "11",
day = "1",
doi = "10.1165/rcmb.2017-0410OC",
language = "English (US)",
volume = "59",
pages = "592--600",
journal = "American Journal of Respiratory Cell and Molecular Biology",
issn = "1044-1549",
publisher = "American Thoracic Society",
number = "5",

}

TY - JOUR

T1 - Maternal cytokine profiles during pregnancy predict asthma in children of mothers without asthma

AU - Rothers, Janet L

AU - Stern, Debra A.

AU - Lohman, I. Carla

AU - Spangenberg, Amber

AU - Wright, Anne L

AU - DeVries, Avery

AU - Vercelli, Donata

AU - Halonen, Marilyn

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune Study, a nonselected birth cohort. Physician-diagnosed active asthma in children through age 9 and a history of asthma in their mothers were assessed through questionnaires. Maternal production of each of the cytokines IL-13, IL-4, IL-5, IFN-g, IL-10, and IL-17 during pregnancy was unrelated to childhood asthma. However, IFN-g/IL-13 and IFN-g/IL-4 ratios during pregnancy were associated with a decreased risk of childhood asthma (n = 381; odds ratio [OR], 0.33; 95% confidence interval [CI], 0.17–0.66; P = 0.002; and n = 368; OR, 0.36; 95% CI, 0.18–0.71; P = 0.003, respectively). The inverse relations of these two ratios with childhood asthma were only evident in mothers without asthma (n = 309; OR, 0.18; 95% CI, 0.08–0.42; P = 0.00007; and n = 299; OR, 0.17; 95% CI, 0.07–0.39; P = 0.00003, respectively) and not in mothers with asthma (n = 72 and 69, respectively; P for interaction by maternal asthma = 0.036 and 0.002, respectively). Paternal cytokine ratios were unrelated to childhood asthma. Maternal cytokine ratios in mothers without asthma were unrelated to the children’s skin-test reactivity, total IgE, physician-confirmed allergic rhinitis at age 5, or eczema in infancy. To our knowledge, this study provides the first evidence that cytokine profiles in pregnant mothers without asthma relate to the risk for childhood asthma, but not allergy, and suggests a process of asthma development that begins in utero and is independent of allergy.

AB - Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune Study, a nonselected birth cohort. Physician-diagnosed active asthma in children through age 9 and a history of asthma in their mothers were assessed through questionnaires. Maternal production of each of the cytokines IL-13, IL-4, IL-5, IFN-g, IL-10, and IL-17 during pregnancy was unrelated to childhood asthma. However, IFN-g/IL-13 and IFN-g/IL-4 ratios during pregnancy were associated with a decreased risk of childhood asthma (n = 381; odds ratio [OR], 0.33; 95% confidence interval [CI], 0.17–0.66; P = 0.002; and n = 368; OR, 0.36; 95% CI, 0.18–0.71; P = 0.003, respectively). The inverse relations of these two ratios with childhood asthma were only evident in mothers without asthma (n = 309; OR, 0.18; 95% CI, 0.08–0.42; P = 0.00007; and n = 299; OR, 0.17; 95% CI, 0.07–0.39; P = 0.00003, respectively) and not in mothers with asthma (n = 72 and 69, respectively; P for interaction by maternal asthma = 0.036 and 0.002, respectively). Paternal cytokine ratios were unrelated to childhood asthma. Maternal cytokine ratios in mothers without asthma were unrelated to the children’s skin-test reactivity, total IgE, physician-confirmed allergic rhinitis at age 5, or eczema in infancy. To our knowledge, this study provides the first evidence that cytokine profiles in pregnant mothers without asthma relate to the risk for childhood asthma, but not allergy, and suggests a process of asthma development that begins in utero and is independent of allergy.

KW - Asthma

KW - Children

KW - Cytokines

KW - Maternal

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85047432677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047432677&partnerID=8YFLogxK

U2 - 10.1165/rcmb.2017-0410OC

DO - 10.1165/rcmb.2017-0410OC

M3 - Article

C2 - 29863910

AN - SCOPUS:85047432677

VL - 59

SP - 592

EP - 600

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

SN - 1044-1549

IS - 5

ER -