Matrix-Assisted Laser Desorption Time of Flight Mass Spectrometry

Donna Wolk, Andrew E. Clark

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Matrix-assisted laser desorption time of flight mass spectrometry (MALDI-TOF MS), adapted for use in clinical microbiology laboratories, challenges current standards of microbial detection and identification. This article summarizes the capabilities of MALDI-TOF MS in diagnostic clinical microbiology laboratories and describes the underpinnings of the technology, highlighting topics such as sample preparation, spectral analysis, and accuracy. The use of MALDI-TOF MS in the clinical microbiology laboratory is growing, and, when properly deployed, can accelerate diagnosis and improve patient care.

Original languageEnglish (US)
Pages (from-to)471-486
Number of pages16
JournalClinics in Laboratory Medicine
Volume38
Issue number3
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

Keywords

  • Bacterial identification
  • Clinical microbiology
  • MALDI-TOF
  • Mass spectrometry
  • Matrix-assisted laser desorption time of flight mass spectrometry

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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