Matrix hyaluronan alters epidermal growth factor receptor-dependent cell morphology

Jeanne M.V. Louderbough, Jose I. Lopez, Joyce A. Schroeder

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

EGFR, a critical regulator of oncogenic signaling during cancer progression, is capable of integrating multireceptor signaling pathways that promote metastasis. EGFRr is subject to regulatory cues from the extracellular matrix (ECM), of which hyaluronan (HA) is a major component. in mammary tumors, HA is deposited in the ECM where it functions in biomechanical support and modulates intracellular signaling. We utilized a 3D collagen system in which is either polymerized in collagen matrix or provided soluble in the media (sHA). Here we report that collagen-embedded (eHA) inhibits EGFR activation, filopodia formation, and cell spreading on a collagen matrix. These findings demonstrate a novel role for eHA as a protective molecule when encountered in the collagen matrix during cancer progression.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalCell Adhesion and Migration
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Collagen
  • EGFR
  • Extracellular matrix
  • HA

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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