Matrix metalloproteinase-9 as a messenger in the cross talk between obstructive sleep apnea and comorbid systemic hypertension, cardiac remodeling, and ischemic stroke: A literature review

Saif Mashaqi, Heidi M. Mansour, Hanan Alameddin, Daniel Combs, Salma Patel, Lauren Estep, Sairam Parthasarathy

Research output: Contribution to journalReview articlepeer-review

Abstract

Study Objectives: OSA is a common sleep disorder. There is a strong link between sleep-related breathing disorders and cardiovascular and cerebrovascular diseases. Matrix metalloproteinase-9 (MMP-9) is a biological marker for extracellular matrix degradation, which plays a significant role in systemic hypertension, myocardial infarction and postmyocardial infarction heart failure, and ischemic stroke. This article reviews MMP-9 as an inflammatory mediator and a potential messenger between OSA and OSA-induced comorbidities. Methods:We reviewed theMEDLINE database (PubMed) for publications onMMP-9, OSA, and cardiovascular disease, identifying 1,592 studies and including and reviewing 50 articles for this work. Results: There is strong evidence that MMP-9 and tissue inhibitor of metalloproteinase-1 levels are elevated in patients with OSA (mainly MMP-9), systemic hypertension, myocardial infarction, and postmyocardial infarction heart failure. Our study showed variable results that could be related to the sample size or to laboratory methodology. Conclusions: MMP-9 and its endogenous inhibitor, tissue inhibitor of metalloproteinase-1, are a common denominator in OSA, systemic hypertension, myocardial infarction, and heart failure. This characterization makes MMP-9 a target for developing novel selective inhibitors that can serve as adjuvant therapy in patients with OSA, which may ameliorate the cardiovascular and cerebrovascular mortality associated with OSA.

Original languageEnglish (US)
Pages (from-to)567-591
Number of pages25
JournalJournal of Clinical Sleep Medicine
Volume17
Issue number3
DOIs
StatePublished - Mar 1 2021

Keywords

  • Hypertension
  • Ischemic stroke
  • Matrix metalloproteinase-9
  • Myocardial infarction
  • OSA
  • Remodeling
  • Tissue inhibitor of metalloproteinase-1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

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