Maximizing chemical diversity of fungal metabolites: Biogenetically related heptaketides of the endolichenic fungus Corynespora sp. (1)

E. M.Kithsiri Wijeratne, Bharat P. Bashyal, Malkanthi K. Gunatilaka, A. Elizabeth Arnold, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

In an attempt to explore the biosynthetic potential of the endolichenic fungus Corynespora sp. BA-10763, its metabolite profiles under several culture conditions were investigated. When cultured in potato dextrose agar, it produced three new heptaketides, 9-O-methylscytalol A (1), 7-desmethylherbarin (2), and 8-hydroxyherbarin (3), together with biogenetically related metabolites scytalol A (4), 8-O-methylfusarubin (5), scorpinone (6), and 8-O-methylbostrycoidin (7), which are new to this organism, and herbarin (8), a metabolite previously encountered in this fungal strain. The use of malt extract agar as the culture medium led to the isolation of 6, 8, 1-hydroxydehydroherbarin (9), and 1-methoxydehydroherbarin (10), which was found to be an artifact formed during the extraction of the culture medium with methanol. The structures of all new compounds were determined by interpretation of their spectroscopic data and chemical interconversions.

Original languageEnglish (US)
Pages (from-to)1156-1159
Number of pages4
JournalJournal Of Natural Products
Volume73
Issue number6
DOIs
StatePublished - Jun 25 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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