Maximizing synthetic efficiency: Multi-component transformations lead the way

Hugues Bienaymé, Chris Hulme, Gilles Oddon, Philippe Schmitt

Research output: Contribution to journalShort survey

1174 Scopus citations

Abstract

With the emergence of high-throughput screening in the pharmaceutical industry in the early 1990's, organic chemists were faced with a new challenge: how to prepare large collections of molecules (the libraries) to "feed" the high-throughput screen? The unique exploratory power of some reactions (such as the 40 year-old Ugi four-component condensation) was soon recognized to be extremely valuable to produce libraries in a time-and cost-effective manner. Over the last five years, industrial and academic researchers have made these powerful transformations into one of the most efficient and cost-effective tools for combinatorial and parallel synthesis.

Original languageEnglish (US)
Pages (from-to)3321-3329
Number of pages9
JournalChemistry - A European Journal
Volume6
Issue number18
DOIs
StatePublished - Sep 15 2000
Externally publishedYes

Keywords

  • Combinatorial chemistry
  • Heterocycles
  • Multicomponent reactions
  • Productivity
  • Synthetic efficiency

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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