Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics

Jinxin Huang, Eric W Clarkson, Matthew A Kupinski, Kye Sung Lee, Kara L. Maki, David S. Ross, James V. Aquavella, Jannick P. Rolland

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Understanding tear film dynamics is a prerequisite for advancing the management of Dry Eye Disease (DED). In this paper, we discuss the use of optical coherence tomography (OCT) and statistical decision theory to analyze the tear film dynamics of a digital phantom. We implement a maximum-likelihood (ML) estimator to interpret OCT data based on mathematical models of Fourier-Domain OCT and the tear film. With the methodology of task-based assessment, we quantify the tradeoffs among key imaging system parameters. We find, on the assumption that the broadband light source is characterized by circular Gaussian statistics, ML estimates of 40 nm +/- 4 nm for an axial resolution of 1 μm and an integration time of 5 μs. Finally, the estimator is validated with a digital phantom of tear film dynamics, which reveals estimates of nanometer precision.

Original languageEnglish (US)
Pages (from-to)1806-1816
Number of pages11
JournalBiomedical Optics Express
Volume4
Issue number10
DOIs
StatePublished - 2013

Fingerprint

Optical Coherence Tomography
Tears
tomography
estimators
statistical decision theory
eye diseases
Decision Theory
maximum likelihood estimates
Likelihood Functions
Eye Diseases
tradeoffs
mathematical models
light sources
Theoretical Models
statistics
methodology
broadband
Light
estimates

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics. / Huang, Jinxin; Clarkson, Eric W; Kupinski, Matthew A; Lee, Kye Sung; Maki, Kara L.; Ross, David S.; Aquavella, James V.; Rolland, Jannick P.

In: Biomedical Optics Express, Vol. 4, No. 10, 2013, p. 1806-1816.

Research output: Contribution to journalArticle

Huang, Jinxin ; Clarkson, Eric W ; Kupinski, Matthew A ; Lee, Kye Sung ; Maki, Kara L. ; Ross, David S. ; Aquavella, James V. ; Rolland, Jannick P. / Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics. In: Biomedical Optics Express. 2013 ; Vol. 4, No. 10. pp. 1806-1816.
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