Measurement of a multi-layered tear film phantom using optical coherence tomography and statistical decision theory

Jinxin Huang, Qun Yuan, Buyun Zhang, Ke Xu, Patrice Tankam, Eric W Clarkson, Matthew A Kupinski, Holly B. Hindman, James V. Aquavella, Thomas J. Suleski, Jannick P. Rolland

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To extend our understanding of tear film dynamics for the management of dry eye disease, we propose a method to optically sense the tear film and estimate simultaneously the thicknesses of the lipid and aqueous layers. The proposed method, SDT-OCT, combines ultra-high axial resolution optical coherence tomography (OCT) and a robust estimator based on statistical decision theory (SDT) to achieve thickness measurements at the nanometer scale. Unlike conventional Fourier-domain OCT where peak detection of layers occurs in Fourier space, in SDT-OCT thickness is estimated using statistical decision theory directly on the raw spectra acquired with the OCT system. In this paper, we demonstrate in simulation that a customized OCT system tailored to ~1 μm axial point spread function (FWHM) in the corneal tissue, combined with the maximum-likelihood estimator, can estimate thicknesses of the nanometer-scale lipid and micron-scale aqueous layers of the tear film, simultaneously, with nanometer precision. This capability was validated in experiments using a physical phantom that consists of two layers of optical coatings that mimic the lipid and aqueous layers of the tear film.

Original languageEnglish (US)
Article numberA4374
Pages (from-to)4374-4386
Number of pages13
JournalBiomedical Optics Express
Volume5
Issue number12
DOIs
StatePublished - 2014

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statistical decision theory
Decision Theory
Optical Coherence Tomography
Tears
tomography
lipids
Lipids
estimators
eye diseases
optical coatings
Eye Diseases
estimates
point spread functions

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Measurement of a multi-layered tear film phantom using optical coherence tomography and statistical decision theory. / Huang, Jinxin; Yuan, Qun; Zhang, Buyun; Xu, Ke; Tankam, Patrice; Clarkson, Eric W; Kupinski, Matthew A; Hindman, Holly B.; Aquavella, James V.; Suleski, Thomas J.; Rolland, Jannick P.

In: Biomedical Optics Express, Vol. 5, No. 12, A4374, 2014, p. 4374-4386.

Research output: Contribution to journalArticle

Huang, J, Yuan, Q, Zhang, B, Xu, K, Tankam, P, Clarkson, EW, Kupinski, MA, Hindman, HB, Aquavella, JV, Suleski, TJ & Rolland, JP 2014, 'Measurement of a multi-layered tear film phantom using optical coherence tomography and statistical decision theory', Biomedical Optics Express, vol. 5, no. 12, A4374, pp. 4374-4386. https://doi.org/10.1364/BOE.5.004374
Huang, Jinxin ; Yuan, Qun ; Zhang, Buyun ; Xu, Ke ; Tankam, Patrice ; Clarkson, Eric W ; Kupinski, Matthew A ; Hindman, Holly B. ; Aquavella, James V. ; Suleski, Thomas J. ; Rolland, Jannick P. / Measurement of a multi-layered tear film phantom using optical coherence tomography and statistical decision theory. In: Biomedical Optics Express. 2014 ; Vol. 5, No. 12. pp. 4374-4386.
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