Measures of asthma control

Christian Bime, Jessica Nguyen, Robert A. Wise

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose of Review: Over the past decade, the concept of asthma control as distinct from asthma severity has been clearly defined. Well controlled asthma is the goal of therapy in all asthma patients. This review is a comprehensive description of the tools currently available for a methodical assessment of different aspects of asthma control in clinical practice and research. Recent Findings: Several questionnaires for assessing asthma control have been extensively validated in adults. In children, validation data are less extensive. Considerable overlap exists between asthma control measures and measures of asthma-specific quality of life. Asthma-specific quality-of-life questionnaires have been used as primary outcome measures in major clinical trials evaluating asthma therapy. Biomarkers that reflect eosinophilic inflammation of the airways are used as intermediate outcome measures to reflect the biological basis of asthma control. There is some controversy, however, over which biomarkers are best incorporated into therapeutic algorithms that attempt to achieve maximal asthma control while minimizing treatment intensity. Summary: In designing clinical studies to evaluate different asthma therapies, researchers will find this review to be a useful resource in terms of choosing the appropriate tool for assessing asthma control. This is also a valuable resource for a methodical assessment of response to asthma therapy in routine clinical care.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
JournalCurrent Opinion in Pulmonary Medicine
Volume18
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Asthma
Therapeutics
Biomarkers
Quality of Life
Outcome Assessment (Health Care)
Research Personnel
Clinical Trials
Inflammation

Keywords

  • asthma
  • asthma control
  • biomarkers
  • quality of life
  • questionnaires

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Measures of asthma control. / Bime, Christian; Nguyen, Jessica; Wise, Robert A.

In: Current Opinion in Pulmonary Medicine, Vol. 18, No. 1, 01.2012, p. 48-56.

Research output: Contribution to journalArticle

Bime, Christian ; Nguyen, Jessica ; Wise, Robert A. / Measures of asthma control. In: Current Opinion in Pulmonary Medicine. 2012 ; Vol. 18, No. 1. pp. 48-56.
@article{015fa65e8ba84dbc8edbeae70ed5dfd1,
title = "Measures of asthma control",
abstract = "Purpose of Review: Over the past decade, the concept of asthma control as distinct from asthma severity has been clearly defined. Well controlled asthma is the goal of therapy in all asthma patients. This review is a comprehensive description of the tools currently available for a methodical assessment of different aspects of asthma control in clinical practice and research. Recent Findings: Several questionnaires for assessing asthma control have been extensively validated in adults. In children, validation data are less extensive. Considerable overlap exists between asthma control measures and measures of asthma-specific quality of life. Asthma-specific quality-of-life questionnaires have been used as primary outcome measures in major clinical trials evaluating asthma therapy. Biomarkers that reflect eosinophilic inflammation of the airways are used as intermediate outcome measures to reflect the biological basis of asthma control. There is some controversy, however, over which biomarkers are best incorporated into therapeutic algorithms that attempt to achieve maximal asthma control while minimizing treatment intensity. Summary: In designing clinical studies to evaluate different asthma therapies, researchers will find this review to be a useful resource in terms of choosing the appropriate tool for assessing asthma control. This is also a valuable resource for a methodical assessment of response to asthma therapy in routine clinical care.",
keywords = "asthma, asthma control, biomarkers, quality of life, questionnaires",
author = "Christian Bime and Jessica Nguyen and Wise, {Robert A.}",
year = "2012",
month = "1",
doi = "10.1097/MCP.0b013e32834db0f2",
language = "English (US)",
volume = "18",
pages = "48--56",
journal = "Current Opinion in Pulmonary Medicine",
issn = "1070-5287",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Measures of asthma control

AU - Bime, Christian

AU - Nguyen, Jessica

AU - Wise, Robert A.

PY - 2012/1

Y1 - 2012/1

N2 - Purpose of Review: Over the past decade, the concept of asthma control as distinct from asthma severity has been clearly defined. Well controlled asthma is the goal of therapy in all asthma patients. This review is a comprehensive description of the tools currently available for a methodical assessment of different aspects of asthma control in clinical practice and research. Recent Findings: Several questionnaires for assessing asthma control have been extensively validated in adults. In children, validation data are less extensive. Considerable overlap exists between asthma control measures and measures of asthma-specific quality of life. Asthma-specific quality-of-life questionnaires have been used as primary outcome measures in major clinical trials evaluating asthma therapy. Biomarkers that reflect eosinophilic inflammation of the airways are used as intermediate outcome measures to reflect the biological basis of asthma control. There is some controversy, however, over which biomarkers are best incorporated into therapeutic algorithms that attempt to achieve maximal asthma control while minimizing treatment intensity. Summary: In designing clinical studies to evaluate different asthma therapies, researchers will find this review to be a useful resource in terms of choosing the appropriate tool for assessing asthma control. This is also a valuable resource for a methodical assessment of response to asthma therapy in routine clinical care.

AB - Purpose of Review: Over the past decade, the concept of asthma control as distinct from asthma severity has been clearly defined. Well controlled asthma is the goal of therapy in all asthma patients. This review is a comprehensive description of the tools currently available for a methodical assessment of different aspects of asthma control in clinical practice and research. Recent Findings: Several questionnaires for assessing asthma control have been extensively validated in adults. In children, validation data are less extensive. Considerable overlap exists between asthma control measures and measures of asthma-specific quality of life. Asthma-specific quality-of-life questionnaires have been used as primary outcome measures in major clinical trials evaluating asthma therapy. Biomarkers that reflect eosinophilic inflammation of the airways are used as intermediate outcome measures to reflect the biological basis of asthma control. There is some controversy, however, over which biomarkers are best incorporated into therapeutic algorithms that attempt to achieve maximal asthma control while minimizing treatment intensity. Summary: In designing clinical studies to evaluate different asthma therapies, researchers will find this review to be a useful resource in terms of choosing the appropriate tool for assessing asthma control. This is also a valuable resource for a methodical assessment of response to asthma therapy in routine clinical care.

KW - asthma

KW - asthma control

KW - biomarkers

KW - quality of life

KW - questionnaires

UR - http://www.scopus.com/inward/record.url?scp=83155181382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83155181382&partnerID=8YFLogxK

U2 - 10.1097/MCP.0b013e32834db0f2

DO - 10.1097/MCP.0b013e32834db0f2

M3 - Article

C2 - 22081089

AN - SCOPUS:83155181382

VL - 18

SP - 48

EP - 56

JO - Current Opinion in Pulmonary Medicine

JF - Current Opinion in Pulmonary Medicine

SN - 1070-5287

IS - 1

ER -