Measuring altered disposition of xenobiotics in experimental models of liver disease

Rhiannon N. Hardwick, Nathan J Cherrington

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Understanding the metabolic pathway and excretion mechanisms governing the disposition of a compound is essential to the safe use of pharmaceutical agents. Because the liver is the primary organ responsible for the metabolism and elimination of xenobiotics, chronic liver disease can have a significant effect on the disposition of many xenobiotics due to changes in the expression or function of drug metabolizing enzymes and transporters. Liver disease can result in increased retention of a xenobiotic within the body, causing greater exposure of the individual to a potentially harmful compound, whichmay lead to toxicity. On the other hand, liver disease may also up-regulate the elimination processes of a xenobiotic, accelerating its removal from the body. With regard to a pharmaceutical agent, enhanced elimination may result in a decreased pharmacologic effect. Such alterations may necessitate dosage adjustments to achieve the desired therapeutic outcome.

Original languageEnglish (US)
Article number23.1
JournalCurrent protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]
Volume1
Issue numberSUPPL.52
DOIs
Publication statusPublished - May 2012

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Keywords

  • Drug disposition
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Steatosis

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

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