Measuring Extracellular pH in a Lung Fibrosis Model with acidoCEST MRI

Kyle M. Jones, Edward A. Randtke, Christine M. Howison, Julio Cárdenas-Rodríguez, Patricia J. Sime, Matthew R. Kottmann, Mark D. Pagel

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Purpose: A feed-forward loop involving lactic acid production may potentially occur during the formation of idiopathic pulmonary fibrosis. To provide evidence for this feed-forward loop, we used acidoCEST MRI to measure the extracellular pH (pHe), while also measuring percent uptake of the contrast agent, lesion size, and the apparent diffusion coefficient (ADC).Procedures: We developed a respiration-gated version of acidoCEST MRI to improve the measurement of pHe and percent uptake in lesions. We also used T2-weighted MRI to measure lesion volumes and diffusion-weighted MRI to measure ADC.Results: The longitudinal changes in average pHe and % uptake of the contrast agent were inversely related to reduction in lung lesion volume. The average ADC did not change during the time frame of the study.Conclusions: The increase in pHe during the reduction in lesion volume indicates a role for lactic acid in the proposed feed-forward loop of IPF

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalMolecular Imaging and Biology
Volume17
Issue number2
DOIs
StatePublished - Jan 1 2015

Keywords

  • CEST
  • Idiopathic pulmonary fibrosis
  • MRI
  • pH

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Jones, K. M., Randtke, E. A., Howison, C. M., Cárdenas-Rodríguez, J., Sime, P. J., Kottmann, M. R., & Pagel, M. D. (2015). Measuring Extracellular pH in a Lung Fibrosis Model with acidoCEST MRI. Molecular Imaging and Biology, 17(2), 177-184. https://doi.org/10.1007/s11307-014-0784-6