Meat intake and the recurrence of colorectal adenomas

A. Mathew, R. Sinha, R. Burt, B. Caan, E. Paskett, F. Iber, W. Kikendall, P. Lance, M. Shike, J. Weissfeld, A. Schatzkin, E. Lanza

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

A large multicenter randomized controlled trial was reassessed to check whether meat intake and a reduction in its consumption are associated with recurrence of adenomatous polyps of the large bowel, which are precursors of most colorectal malignancies. All subjects (n = 1905; 958 interventions and 947 controls) had one or more histologically confirmed colorectal adenomas removed during a colonoscopy within 6 months before randomization. The subjects were followed-up for approximately 4 years after randomization and a colonoscopy for detecting adenomas was conducted at the 1st and 4th year after randomization. Dietary variables were assessed at baseline (T0) and in conjunction with annual visits at the end of the 1st (T1), 2nd (T2), 3rd (T3) and 4th (T4) years. Odds ratios using logistic regression models for meat variables were estimated based on the average intake at T0, T1, T2, T3 and T4 (prior to the T4 colonoscopy) as well as change (T0-T4) in intake. In the intervention group, the total reduction in median intake of red meat from T0 to T4 was observed by the end of 1st year itself (30 and 31% for men and women, respectively). The analysis provide no evidence to suggest that lower intake or reduction in total and in red meat consumption during a period of 4 years reduces the risk of adenoma recurrence (including multiple or advanced adenoma), whereas the data suggest that high intake of fish is associated with lower risk of adenoma recurrence.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalEuropean Journal of Cancer Prevention
Volume13
Issue number3
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

Keywords

  • Recurrent colorectal adenomas
  • Red meat
  • White meat

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Fingerprint Dive into the research topics of 'Meat intake and the recurrence of colorectal adenomas'. Together they form a unique fingerprint.

  • Cite this

    Mathew, A., Sinha, R., Burt, R., Caan, B., Paskett, E., Iber, F., Kikendall, W., Lance, P., Shike, M., Weissfeld, J., Schatzkin, A., & Lanza, E. (2004). Meat intake and the recurrence of colorectal adenomas. European Journal of Cancer Prevention, 13(3), 159-164. https://doi.org/10.1097/01.cej.0000130022.23806.7b