Mechanics and computational simulation of blood flow in microvessels

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Blood is a concentrated suspension of red blood cells (RBCs). Motion and deformation of RBCs can be analyzed based on knowledge of their mechanical characteristics. Axisymmetric models for single-file motion of RBCs in capillaries yield predictions of apparent viscosity in good agreement with experimental results for diameters up to about 8 μm. Two-dimensional simulations, in which each RBC is represented as a set of interconnected viscoelastic elements, predict that off-centre RBCs in an 8-μm channel take asymmetric shapes and drift toward the centre-line. Predicted trajectories agree with observations in microvessels of the rat mesentery. An isolated RBC initially positioned near the wall of a 20-μm channel is deformed into an asymmetric shape, migrates away from the wall, and then enters a complex tumbling motion with continuous shape change. Realistic simulation of multiple interacting RBCs in microvessels remains as a major challenge.

Original languageEnglish (US)
Pages (from-to)800-804
Number of pages5
JournalMedical Engineering and Physics
Volume33
Issue number7
DOIs
StatePublished - Sep 2011

Fingerprint

Microvessels
Mechanics
Blood
Erythrocytes
Mesentery
Barreling
Viscosity
Suspensions
Rats
Cells
Trajectories

Keywords

  • Blood flow
  • Capillary
  • Microcirculation
  • Red blood cell

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

Cite this

Mechanics and computational simulation of blood flow in microvessels. / Secomb, Timothy W.

In: Medical Engineering and Physics, Vol. 33, No. 7, 09.2011, p. 800-804.

Research output: Contribution to journalArticle

@article{35140a274d3f4511b943c67b73f0a6c6,
title = "Mechanics and computational simulation of blood flow in microvessels",
abstract = "Blood is a concentrated suspension of red blood cells (RBCs). Motion and deformation of RBCs can be analyzed based on knowledge of their mechanical characteristics. Axisymmetric models for single-file motion of RBCs in capillaries yield predictions of apparent viscosity in good agreement with experimental results for diameters up to about 8 μm. Two-dimensional simulations, in which each RBC is represented as a set of interconnected viscoelastic elements, predict that off-centre RBCs in an 8-μm channel take asymmetric shapes and drift toward the centre-line. Predicted trajectories agree with observations in microvessels of the rat mesentery. An isolated RBC initially positioned near the wall of a 20-μm channel is deformed into an asymmetric shape, migrates away from the wall, and then enters a complex tumbling motion with continuous shape change. Realistic simulation of multiple interacting RBCs in microvessels remains as a major challenge.",
keywords = "Blood flow, Capillary, Microcirculation, Red blood cell",
author = "Secomb, {Timothy W}",
year = "2011",
month = "9",
doi = "10.1016/j.medengphy.2010.09.016",
language = "English (US)",
volume = "33",
pages = "800--804",
journal = "Medical Engineering and Physics",
issn = "1350-4533",
publisher = "Elsevier BV",
number = "7",

}

TY - JOUR

T1 - Mechanics and computational simulation of blood flow in microvessels

AU - Secomb, Timothy W

PY - 2011/9

Y1 - 2011/9

N2 - Blood is a concentrated suspension of red blood cells (RBCs). Motion and deformation of RBCs can be analyzed based on knowledge of their mechanical characteristics. Axisymmetric models for single-file motion of RBCs in capillaries yield predictions of apparent viscosity in good agreement with experimental results for diameters up to about 8 μm. Two-dimensional simulations, in which each RBC is represented as a set of interconnected viscoelastic elements, predict that off-centre RBCs in an 8-μm channel take asymmetric shapes and drift toward the centre-line. Predicted trajectories agree with observations in microvessels of the rat mesentery. An isolated RBC initially positioned near the wall of a 20-μm channel is deformed into an asymmetric shape, migrates away from the wall, and then enters a complex tumbling motion with continuous shape change. Realistic simulation of multiple interacting RBCs in microvessels remains as a major challenge.

AB - Blood is a concentrated suspension of red blood cells (RBCs). Motion and deformation of RBCs can be analyzed based on knowledge of their mechanical characteristics. Axisymmetric models for single-file motion of RBCs in capillaries yield predictions of apparent viscosity in good agreement with experimental results for diameters up to about 8 μm. Two-dimensional simulations, in which each RBC is represented as a set of interconnected viscoelastic elements, predict that off-centre RBCs in an 8-μm channel take asymmetric shapes and drift toward the centre-line. Predicted trajectories agree with observations in microvessels of the rat mesentery. An isolated RBC initially positioned near the wall of a 20-μm channel is deformed into an asymmetric shape, migrates away from the wall, and then enters a complex tumbling motion with continuous shape change. Realistic simulation of multiple interacting RBCs in microvessels remains as a major challenge.

KW - Blood flow

KW - Capillary

KW - Microcirculation

KW - Red blood cell

UR - http://www.scopus.com/inward/record.url?scp=79961028803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79961028803&partnerID=8YFLogxK

U2 - 10.1016/j.medengphy.2010.09.016

DO - 10.1016/j.medengphy.2010.09.016

M3 - Article

VL - 33

SP - 800

EP - 804

JO - Medical Engineering and Physics

JF - Medical Engineering and Physics

SN - 1350-4533

IS - 7

ER -