Mechanism-based isolation and structures of some anticancer active natural products

Leslie Gunatilaka, David G I Kingston, Randall K. Johnson

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Application of a mechanism-based anticancer bioassay employing DNA repair-or recombination-deficient mutants of the yeast Saccharomyces cerevisiae for screening and subsequent bioassay-guided fractionation of bioactive higher plant and bryophyte extracts led to the isolation of a variety of natural products with potential anticancer activity. Presented herein are interesting structural features of some representative examples of natural products active in our mechanism-based bioassay and cytotoxicity assays along with structure-activity relationships of synthetic analogs of some of them.

Original languageEnglish (US)
Pages (from-to)2219-2222
Number of pages4
JournalPure and Applied Chemistry
Volume66
Issue number10-11
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Bioassay
Biological Products
Yeast
Plant Extracts
Cytotoxicity
Fractionation
Assays
Screening
DNA
Repair

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Mechanism-based isolation and structures of some anticancer active natural products. / Gunatilaka, Leslie; Kingston, David G I; Johnson, Randall K.

In: Pure and Applied Chemistry, Vol. 66, No. 10-11, 01.01.1994, p. 2219-2222.

Research output: Contribution to journalArticle

Gunatilaka, Leslie ; Kingston, David G I ; Johnson, Randall K. / Mechanism-based isolation and structures of some anticancer active natural products. In: Pure and Applied Chemistry. 1994 ; Vol. 66, No. 10-11. pp. 2219-2222.
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