Mechanism of action of epinephrine in resuscitation from asphyxial arrest.

Charles W Otto, R. W. Yakaitis, C. D. Blitt

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Abstract

To determine the relative importance of the alpha and beta adrenergic effects of epinephrine in resuscitation, 32 dogs were studied in four groups. Group A (alpha blocked) received phenoxybenzamine, 70 mg/kg; group B (beta blocked), propranolol 5 mg/kg; group C (alpha and beta blocked) both drugs; and group D (control), no drug. After this treatment and 5 min of asphyxial arrest, all animals received closed chest cardiac massage (CCCM), artificial ventilation (AR), and epinephrine, 1 mg, iv. Resumption of spontaneous circulation occurred with the following frequency: group A, 0/8; group B, 6/8, group C, 0/8, group D, 7/8. The difference in successful resuscitation of the alpha blocked animals and the not alpha blocked animals is statistically significant (P less than or equal to 0.01). It is concluded that the efficacy of epinephrine in aiding resumption of spontaneous circulation from asphyxial arrest is due to alpha adrenergic receptor stimulation and that beta receptor stimulation is not important in determining outcome.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalCritical Care Medicine
Volume9
Issue number4
Publication statusPublished - Apr 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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