Mechanism of action of retinyl compounds on wound healing III: Effect of retinoic acid homologs on granuloma formation

K. H. Lee, Cherng‐Chyi ‐C Fu, Michael R. Spencer, Theodore G. Tong, Richard Poon

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A series of homologs of retinoic acid was synthesized. The activities of these compounds on granuloma formation induced by implanted cotton pellets were studied. The compound (β‐C22 acid) with two more carbons on the side chain of retinoic acid is the most active. The hexosamine and hydroxyproline contents in the granuloma affected by these compounds are also increased. The mechanisms of action of these compounds on wound healing are discussed.

Original languageEnglish (US)
Pages (from-to)895-899
Number of pages5
JournalJournal of pharmaceutical sciences
Volume62
Issue number6
DOIs
StatePublished - Jun 1973
Externally publishedYes

Keywords

  • Granuloma formation—synthesis, effect and mechanism of retinoic acid analogs
  • Retinoic acid analogs—synthesis, effect and mechanism on granuloma formation
  • Structure‐activity relationships—effect of retinoic acid analogs containing 2,6,6‐trimethylcyclohex‐1‐ene ring on granuloma formation
  • Wound healing—synthesis of retinoic acid analogs, effect and mechanism on granuloma formation

ASJC Scopus subject areas

  • Pharmaceutical Science

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