Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH

Katrina M Miranda, Andrew S. Dutton, Lisa A. Ridnour, Christian A. Foreman, Eleonora Ford, Nazareno Paolocci, Tatsuo Katori, Carlo G. Tocchetti, Daniele Mancardi, Douglas D. Thomas, Michael G. Espey, K. N. Houk, Jon M. Fukuto, David A. Wink

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.

Original languageEnglish (US)
Pages (from-to)722-731
Number of pages10
JournalJournal of the American Chemical Society
Volume127
Issue number2
DOIs
StatePublished - Jan 19 2005

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Sodium
Salts
Decomposition
Nitrogen oxides
Nitric Oxide
Pyrolysis
Cardiovascular Diseases
Heart Failure
Hot Temperature
oxyhyponitrite

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH. / Miranda, Katrina M; Dutton, Andrew S.; Ridnour, Lisa A.; Foreman, Christian A.; Ford, Eleonora; Paolocci, Nazareno; Katori, Tatsuo; Tocchetti, Carlo G.; Mancardi, Daniele; Thomas, Douglas D.; Espey, Michael G.; Houk, K. N.; Fukuto, Jon M.; Wink, David A.

In: Journal of the American Chemical Society, Vol. 127, No. 2, 19.01.2005, p. 722-731.

Research output: Contribution to journalArticle

Miranda, KM, Dutton, AS, Ridnour, LA, Foreman, CA, Ford, E, Paolocci, N, Katori, T, Tocchetti, CG, Mancardi, D, Thomas, DD, Espey, MG, Houk, KN, Fukuto, JM & Wink, DA 2005, 'Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH', Journal of the American Chemical Society, vol. 127, no. 2, pp. 722-731. https://doi.org/10.1021/ja045480z
Miranda, Katrina M ; Dutton, Andrew S. ; Ridnour, Lisa A. ; Foreman, Christian A. ; Ford, Eleonora ; Paolocci, Nazareno ; Katori, Tatsuo ; Tocchetti, Carlo G. ; Mancardi, Daniele ; Thomas, Douglas D. ; Espey, Michael G. ; Houk, K. N. ; Fukuto, Jon M. ; Wink, David A. / Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 2. pp. 722-731.
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