Mechanisms and function of intercellular calcium signaling

Michael J. Sanderson, Andrew C. Charles, Scott A Boitano, Ellen R. Dirksen

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

Intercellular Ca2+ waves initiated by mechanical or chemical stimuli propagate between cells via gap junctions. The ability of a wide diversity of cells to display intercellular Ca2+ waves suggests that these Ca2+ waves may represent a general mechanism by which cells communicate. Although Ca2+ may permeate gap junctions, the intercellular movement of Ca2+ is not essential for the propagation of Ca2+ waves. The messenger that moves from one cell to the next through gap junctions appears to be IP3 and a regenerative mechanism for IP3 may be required to effect multicellular communication. Extracellularly mediated Ca2+ signaling also exists and this could be employed to supplement or replace gap junctional communication. The function of intercellular Ca2+ waves may be the coordination of cooperative cellular responses to local stimuli.

Original languageEnglish (US)
Pages (from-to)173-187
Number of pages15
JournalMolecular and Cellular Endocrinology
Volume98
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Calcium Signaling
Gap Junctions
Calcium
Communication

Keywords

  • Airway epithelial cell
  • Calcium wave
  • Gap junction
  • Glia cell
  • Inositol trisphosphate
  • Intercellular communication
  • Mechanical stimulation
  • Oscillation

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Mechanisms and function of intercellular calcium signaling. / Sanderson, Michael J.; Charles, Andrew C.; Boitano, Scott A; Dirksen, Ellen R.

In: Molecular and Cellular Endocrinology, Vol. 98, No. 2, 1994, p. 173-187.

Research output: Contribution to journalArticle

Sanderson, Michael J. ; Charles, Andrew C. ; Boitano, Scott A ; Dirksen, Ellen R. / Mechanisms and function of intercellular calcium signaling. In: Molecular and Cellular Endocrinology. 1994 ; Vol. 98, No. 2. pp. 173-187.
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