Mechanisms of Endothelial Injury and Blood-Brain Barrier Dysfunction in Stroke

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The blood-brain barrier (BBB) regulates CNS homeostasis and is the most significant obstacle to effective brain drug delivery. It possesses characteristics (i.e., tight junction protein complexes, influx and efflux transporters) that control permeation of circulating solutes including therapeutic agents. Ischemic stroke can cause injury to the brain microvascular endothelium at both the structural and functional level, which leads to considerable BBB dysfunction and significant CNS pathology. Several pathophysiological mechanisms (i.e., oxidative stress, inflammation) have been identified that can mediate BBB dysfunction during ischemic stroke. This chapter summarizes current knowledge in this area and highlights novel pharmacological approaches that can be utilized for protection against injury to brain microvascular endothelial cells in the setting of stroke.

Original languageEnglish (US)
Title of host publicationPrimer on Cerebrovascular Diseases
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages220-226
Number of pages7
ISBN (Print)9780128030585
DOIs
StatePublished - Mar 7 2017

Keywords

  • Blood-brain barrier
  • Drug transporter
  • Endothelial cell
  • Hypoxia
  • Inflammation
  • Oxidative stress
  • Pharmacotherapy
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

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