Mechanisms of the antioxidant effects of nitric oxide

David A. Wink, Katrina M Miranda, Michael G. Espey, Ryzard M. Pluta, Sandra J. Hewett, Carol Colton, Michael Vitek, Martin Feelisch, Mathew B. Grisham

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

The Janus face of nitric oxide (NO) has prompted a debate as to whether NO plays a deleterious or protective role in tissue injury. There are a number of reactive nitrogen oxide species, such as N2O3 and ONOO-, that can alter critical cellular components under high local concentrations of NO. However, NO can also abate the oxidation chemistry mediated by reactive oxygen species such as H2O2 and O2- that occurs at physiological levels of NO. In addition to the antioxidant chemistry, NO protects against cell death mediated by H2O2, alkylhydroperoxides, and xanthine oxidase. The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress.

Original languageEnglish (US)
Pages (from-to)203-213
Number of pages11
JournalAntioxidants and Redox Signaling
Volume3
Issue number2
StatePublished - Apr 2001
Externally publishedYes

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Nitric Oxide
Antioxidants
Wounds and Injuries
Physiological Phenomena
Reactive Nitrogen Species
Oxidative stress
Xanthine Oxidase
Peroxides
Cell death
Lipid Peroxidation
Free Radicals
Reactive Oxygen Species
Oxidative Stress
Leukocytes
Cell Death
Adhesion
Metals
Cells
Tissue
Lipids

ASJC Scopus subject areas

  • Biochemistry

Cite this

Wink, D. A., Miranda, K. M., Espey, M. G., Pluta, R. M., Hewett, S. J., Colton, C., ... Grisham, M. B. (2001). Mechanisms of the antioxidant effects of nitric oxide. Antioxidants and Redox Signaling, 3(2), 203-213.

Mechanisms of the antioxidant effects of nitric oxide. / Wink, David A.; Miranda, Katrina M; Espey, Michael G.; Pluta, Ryzard M.; Hewett, Sandra J.; Colton, Carol; Vitek, Michael; Feelisch, Martin; Grisham, Mathew B.

In: Antioxidants and Redox Signaling, Vol. 3, No. 2, 04.2001, p. 203-213.

Research output: Contribution to journalArticle

Wink, DA, Miranda, KM, Espey, MG, Pluta, RM, Hewett, SJ, Colton, C, Vitek, M, Feelisch, M & Grisham, MB 2001, 'Mechanisms of the antioxidant effects of nitric oxide', Antioxidants and Redox Signaling, vol. 3, no. 2, pp. 203-213.
Wink DA, Miranda KM, Espey MG, Pluta RM, Hewett SJ, Colton C et al. Mechanisms of the antioxidant effects of nitric oxide. Antioxidants and Redox Signaling. 2001 Apr;3(2):203-213.
Wink, David A. ; Miranda, Katrina M ; Espey, Michael G. ; Pluta, Ryzard M. ; Hewett, Sandra J. ; Colton, Carol ; Vitek, Michael ; Feelisch, Martin ; Grisham, Mathew B. / Mechanisms of the antioxidant effects of nitric oxide. In: Antioxidants and Redox Signaling. 2001 ; Vol. 3, No. 2. pp. 203-213.
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