Mechanisms regulating endothelial cell barrier function

Troy Stevens, Joe G.N. Garcia, D. Michael Shasby, Jahar Bhattacharya, Asrar B. Malik

Research output: Contribution to journalArticlepeer-review

193 Scopus citations

Abstract

Endothelium forms a physical barrier that separates blood from tissue. Communication between blood and tissue occurs through the delivery of molecules and circulating substances across the endothelial barrier by directed transport either through or between cells. Inflammation promotes macromolecular transport by decreasing cell-cell and cell-matrix adhesion and increasing centripetally directed tension, resulting in the formation of intercellular gaps. Inflammation may also increase the selected transport of macromolecules through cells. Significant progress has been made in understanding the molecular and cellular mechanisms that account for constitutive endothelial cell barrier function and also the mechanisms activated during inflammation that reduce barrier function. Current concepts of mechanisms regulating endothelial cell barrier function were presented in a symposium at the 2000 Experimental Biology Conference and are reviewed here.

Original languageEnglish (US)
Pages (from-to)L419-L422
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume279
Issue number3 23-3
DOIs
StatePublished - 2000

Keywords

  • Adenyl cyclase
  • Calcium
  • Gp60
  • Myosin light chain kinase
  • Vascular endothelial-cadherin

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

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