Mechanisms that generate and maintain bone cancer pain

Patrick W Mantyh, Stephen P. Hunt, Blake, Fox, Felson, Kuettner, Schaible, Kidd, Grubb, Mackenzie

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Citations (Scopus)

Abstract

Although bone cancer pain can be severe and is relatively common, as it frequently arises from metastases from breast, prostate, and lung tumours, very little is known about the basic mechanisms that generate and maintain this chronic pain. To begin to define the mechanisms that give rise to bone cancer pain, we have developed mouse and rat models using the intramedullary injection and containment of tumour cells into the femur. These tumour cells induced bone remodelling as well as ongoing and movement evoked pain behaviours similar to that found in patients with bone cancer pain. In addition there is a significant reorganization of the spinal cord that received sensory input from the cancerous bone and this reorganization generated a neurochemical signature of bone cancer pain that is both dramatic and significantly different from that observed in mouse and rat models of chronic neuropathic or inflammatory pain. These models have provided insight into the mechanisms that drive cancer pain and have begun to allow the development of mechanism-based therapies. Together these advances should reduce tumour-induced pain and suffering and significantly improve the quality of life of cancer patients.

Original languageEnglish (US)
Title of host publicationNovartis Foundation Symposium
Pages221-240
Number of pages20
Volume260
StatePublished - 2004
Externally publishedYes

Publication series

NameNovartis Foundation Symposium
Volume260

Fingerprint

Bone Neoplasms
Neoplasms
Pain
Bone Remodeling
Psychological Stress
Chronic Pain
Femur
Prostate
Spinal Cord
Breast
Quality of Life
Cancer Pain
Neoplasm Metastasis
Bone and Bones
Lung
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mantyh, P. W., Hunt, S. P., Blake, Fox, Felson, Kuettner, ... Mackenzie (2004). Mechanisms that generate and maintain bone cancer pain. In Novartis Foundation Symposium (Vol. 260, pp. 221-240). (Novartis Foundation Symposium; Vol. 260).

Mechanisms that generate and maintain bone cancer pain. / Mantyh, Patrick W; Hunt, Stephen P.; Blake; Fox; Felson; Kuettner; Schaible; Kidd; Grubb; Mackenzie.

Novartis Foundation Symposium. Vol. 260 2004. p. 221-240 (Novartis Foundation Symposium; Vol. 260).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mantyh, PW, Hunt, SP, Blake, Fox, Felson, Kuettner, Schaible, Kidd, Grubb & Mackenzie 2004, Mechanisms that generate and maintain bone cancer pain. in Novartis Foundation Symposium. vol. 260, Novartis Foundation Symposium, vol. 260, pp. 221-240.
Mantyh PW, Hunt SP, Blake, Fox, Felson, Kuettner et al. Mechanisms that generate and maintain bone cancer pain. In Novartis Foundation Symposium. Vol. 260. 2004. p. 221-240. (Novartis Foundation Symposium).
Mantyh, Patrick W ; Hunt, Stephen P. ; Blake ; Fox ; Felson ; Kuettner ; Schaible ; Kidd ; Grubb ; Mackenzie. / Mechanisms that generate and maintain bone cancer pain. Novartis Foundation Symposium. Vol. 260 2004. pp. 221-240 (Novartis Foundation Symposium).
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