Mechanosensing can result from adhesion molecule dynamics

Paulina Krzyszczyk, Charles William Wolgemuth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

When plated onto a substrate, cells spread. Many cell types, including smooth muscle cells and fibroblasts, spread more effectively on stiffer substrates, and a simple empirical relationship has been determined that relates a cell's spread area to the substrate stiffness. In addition, some crawling cells when plated onto a stiff substrate will not migrate onto soft substrate, a process called "durotaxis". Here we show that the resistive force predicted previously for dynamic adhesion molecules can account for both of these mechanosensory effects.

Original languageEnglish (US)
JournalBiophysical Journal
Volume101
Issue number10
DOIs
StatePublished - Nov 16 2011
Externally publishedYes

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Smooth Muscle Myocytes
Fibroblasts

ASJC Scopus subject areas

  • Biophysics

Cite this

Mechanosensing can result from adhesion molecule dynamics. / Krzyszczyk, Paulina; Wolgemuth, Charles William.

In: Biophysical Journal, Vol. 101, No. 10, 16.11.2011.

Research output: Contribution to journalArticle

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